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FeNO as a predictor of asthma control improvement after starting inhaled steroid treatment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
2014 (English)In: Nitric oxide, ISSN 1089-8603, E-ISSN 1089-8611, Vol. 40, 110-116 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: The fraction of NO in exhaled air (FeNO) is a marker of inflammation in asthma. The aim of the present study was to assess, in a real-world setting, whether only high ( >= 50 ppb) FeNO levels predict improvement in asthma control when being treated with inhaled corticosteroids (ICS), as suggested by current guidelines on the clinical use of FeNO. Methods: FeNO and asthma control were assessed in a retrospective observational study in 153 non-smoking, steroid-nave, adult subjects with asthma with a mean age of 40 years both before and after 6 weeks (median follow-up time) of treatment with 500 mu g beclomethasone (median). Results: Having at the initial visit intermediate FeNO ( >= 25 and <50 ppb) and high FeNO ( >= 50 ppb), compared to normal FeNO (<25 ppb), were associated with a larger proportion of subjects achieving an improvement of Asthma Control Questionnaire (ACQ) score with >= 1 (78% and 67% vs 43%, p <0.05) or both >= 1 improvement and asthma control at follow-up (31% and 37% vs 4%, p < 0.05). These associations were consistent in multiple logistic regression models after adjustments for confounders. Conclusions: It is not only high but also intermediate FeNO levels that are associated with a significant improvement in asthma control after starting ICS treatment. This challenges current clinical guidelines stating that only high FeNO levels predict response to ICS treatment.

Place, publisher, year, edition, pages
2014. Vol. 40, 110-116 p.
Keyword [en]
Asthma control, ACQ, Exhaled nitric oxide, Lung function, Real-life study, Longitudinal study
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-232591DOI: 10.1016/j.niox.2014.06.009ISI: 000340701200016OAI: oai:DiVA.org:uu-232591DiVA: diva2:749549
Available from: 2014-09-24 Created: 2014-09-22 Last updated: 2017-12-05Bibliographically approved

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Malinovschi, Andrei

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