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Influence of persistent organic pollutants on the complement system in a population-based human sample
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.ORCID iD: 0000-0002-8949-3555
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
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2014 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 71, 94-100 p.Article in journal (Refereed) Published
Abstract [en]

Background: Persistent organic pollutants (POPS) are toxic compounds generated through various industrial activities and have adverse effects on human health. Studies performed in cell cultures and animals have revealed that POPs can alter immune-system functioning. The complement system is part of innate immune system that helps to clear pathogens from the body. We performed a large-scale population-based study to find out associations between summary measures of different POPs and different complement system markers. Methods: In this cross-sectional study, 16 polychlorinated biphenyls (PCBs), 3 organochlorine (OC) pesticides, octachloro-p-dibenzodioxin, and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) were analyzed for their association with levels of protein complement 3 (C3), 3a (C3a), 4 (C4) and C3a/C3 ratio. A total of 992 individuals (all aged 70 years, 50% females) were recruited from the Prospective Investigation of the Vasculature in Uppsala Seniors cohort. Regression analysis adjusting for a variety of confounders was performed to study the associations of different POP exposures (total toxic equivalency value or TEQ and sum of 16 PCBs) with protein complements. Results: The TEQ values were found to be positively associated with C3a (beta = 0.07, 95% CI = 0.017-0.131, p = 0.01) and C3a/C3 ratio (beta = 0.07, 95% Cl = 0.015-0.126, p = 0.01) taking possible confounders into account. The association observed was mainly driven by PCB-126. Conclusion: In this study involving 992 elderly individuals from the general population, we showed that POPs, mainly PCB-126, were associated with levels of complement system markers indicating that the association of these toxic compounds with downstream disease could be mediated by activation of immune system.

Place, publisher, year, edition, pages
2014. Vol. 71, 94-100 p.
Keyword [en]
Complement system markers, Epidemiology, Persistent organic pollutants, TEQ
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:uu:diva-232568DOI: 10.1016/j.envint.2014.06.009ISI: 000341745100011PubMedID: 24996157OAI: oai:DiVA.org:uu-232568DiVA: diva2:749648
Funder
Swedish Research CouncilSwedish Research Council for Environment, Agricultural Sciences and Spatial PlanningSwedish Heart Lung Foundation
Available from: 2014-09-24 Created: 2014-09-22 Last updated: 2017-12-05Bibliographically approved

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Kumar, JitenderLind, P. MonicaSalihovic, SamiraEkdahl, Kristina NilssonLind, LarsIngelsson, Erik

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Kumar, JitenderLind, P. MonicaSalihovic, SamiraEkdahl, Kristina NilssonLind, LarsIngelsson, Erik
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Molecular epidemiologyScience for Life Laboratory, SciLifeLabOccupational and Environmental MedicineCardiovascular epidemiologyClinical Immunology
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Environment International
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