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Accurate macromolecular structures using minimal measurements from X-ray free-electron lasers
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2014 (English)In: Nature Methods, ISSN 1548-7091, E-ISSN 1548-7105, Vol. 11, no 5, 545-548 p.Article in journal (Refereed) Published
Abstract [en]

X-ray free-electron laser (XFEL) sources enable the use of crystallography to solve three-dimensional macromolecular structures under native conditions and without radiation damage. Results to date, however, have been limited by the challenge of deriving accurate Bragg intensities from a heterogeneous population of microcrystals, while at the same time modeling the X-ray spectrum and detector geometry. Here we present a computational approach designed to extract meaningful high-resolution signals from fewer diffraction measurements.

Place, publisher, year, edition, pages
2014. Vol. 11, no 5, 545-548 p.
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Structural Biology
URN: urn:nbn:se:uu:diva-232835DOI: 10.1038/nmeth.2887PubMedID: 24633409OAI: oai:DiVA.org:uu-232835DiVA: diva2:749979
Available from: 2014-09-25 Created: 2014-09-25 Last updated: 2014-10-01Bibliographically approved

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Seibert, M Marvin
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