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Exploiting genomics, genetics and chemistry to combat antibiotic resistance
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
2003 (English)In: Nature reviews genetics, ISSN 1471-0056, E-ISSN 1471-0064, Vol. 4, no 6, 432-441 p.Article, review/survey (Refereed) Published
Abstract [en]

To address the worsening problem of antibiotic-resistant bacteria there is an urgent need to develop new antibiotics. Comparative genomics and molecular genetics are being applied to produce lists of essential new targets for compound screening programmes. Combinatorial chemistry and structural biology are being applied to rapidly explore and optimize the interactions between lead compounds and their biological targets. Several compounds that have been identified from target-based screens are now in development, but technical and economic constraints might result in a trickle, rather than a flood, of new antibiotics onto the market in the near future.

Place, publisher, year, edition, pages
2003. Vol. 4, no 6, 432-441 p.
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Microbiology in the medical area
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URN: urn:nbn:se:uu:diva-47242DOI: 10.1038/nrg1084OAI: oai:DiVA.org:uu-47242DiVA: diva2:75149
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-05Bibliographically approved

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