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A new mutation in 16S rRNA of Escherichia coli conferring spectinomycin resistance
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Molecular Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Molecular Biology.
1995 (English)In: Nucleic Acids Research, ISSN 0305-1048, E-ISSN 1362-4962, Vol. 23, no 3, 464-466 p.Article in journal (Refereed) Published
Abstract [en]

We report a novel mutation, Cl 066U in 16S rRNA whichwas selected for resistance to spectinomycin, anantibiotic which inhibits ribosomal translocation. Theminimal inhibitory concentration (MIC) of spectinomycindetermined for this mutant (15 pg/ml) is greaterthan with the wild-type plasmid (5 ig/ml) but lower thanwith the well known C1192U mutation (>80 pg/ml). TheCl 066U mutation also increases the cells sensitivity tofusidic acid, another antibiotic which inhibits translationat the translocation stage, whereas C1192U isunchanged relative to the wild type. We discuss whythe acquisition of resistance to one of these drugs isoften associated with hypersensitivity to the other.

Place, publisher, year, edition, pages
1995. Vol. 23, no 3, 464-466 p.
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Microbiology in the medical area
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URN: urn:nbn:se:uu:diva-47250OAI: oai:DiVA.org:uu-47250DiVA: diva2:75157
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-05Bibliographically approved

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Hughes, Diarmaid

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