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The role of EF-Tu and other translation components in determining translocation step size
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Molecular Biology.
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1990 (English)In: Biochimica et Biophysica Acta, Gene Structure and Expression, ISSN 0167-4781, E-ISSN 1879-2634, Vol. 1050, no 1-3, 274-278 p.Article in journal (Refereed) Published
Abstract [en]

The two EF-Tu encoding genes, tufA and tufB, of Salmonella typhimurium have been sequenced. Nearly all the differences from their Escherichia coli counterparts are third position changes which do not alter the encoded amino acids. Unexpectedly, most of the changes in one Salmonella tuf gene are paralleled by changes in the other tuf gene perhaps due to gene repair despite the distance separating the genes. Three mutants which cause mis-framing, have their substitutions at codon 375. Explanations for mutants which cause mis-framing are considered and the mechanism of normal reading frame maintenance discussed.

Place, publisher, year, edition, pages
1990. Vol. 1050, no 1-3, 274-278 p.
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Microbiology in the medical area
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URN: urn:nbn:se:uu:diva-47260DOI: 10.1016/0167-4781(90)90180-AOAI: oai:DiVA.org:uu-47260DiVA: diva2:75167
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2017-12-05Bibliographically approved

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Hughes, Diarmaid

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