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Development of a Resorbable Calcium Phosphate Cement with Load Bearing Capacity
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)
2014 (English)In: Bioceramics Development and Applications, ISSN 2090-5017, E-ISSN 2090-5025, Vol. 4, no 1, 1000074- p.Article in journal (Refereed) Published
Abstract [en]

Compared to cortical bone and polymeric bone cements, the mechanical properties of calcium phosphate cements are generally poor. This has resulted in them being used in non-load bearing clinical applications. The aim of this study was to investigate the possibility of producing a brushite cement with mechanical properties closer to those of cortical bone (i.e., >100 MPa in compression), i.e. with a potential to be used in load bearing applications. With a compressive strength of 74.4 (± 10.7) MPa, maximum at 91.8 MPa, the cement presented herein is comparable with the non degradable polymeric counterparts and the strongest hydroxyapatite cements, and is close in strength of cortical bone. Furthermore, it has a high injectability (>90%) and a setting time of approximately 17 minutes. A cement comprising these properties has great potential of changing the future clinical indications for calcium phosphate cements, and could potentially reduce the use of non-degradable polymeric cements.

Place, publisher, year, edition, pages
2014. Vol. 4, no 1, 1000074- p.
Keyword [en]
Brushite, Cement, Calcium phosphate, Strongest
National Category
Ceramics Medical Materials
Research subject
Engineering Science with specialization in Materials Science
URN: urn:nbn:se:uu:diva-233540DOI: 10.4172/2090-5025.1000074OAI: oai:DiVA.org:uu-233540DiVA: diva2:753149
EU, FP7, Seventh Framework ProgrammeSwedish Research Council
Available from: 2014-10-07 Created: 2014-10-07 Last updated: 2015-02-03Bibliographically approved
In thesis
1. Physical Properties of Acidic Calcium Phosphate Cements
Open this publication in new window or tab >>Physical Properties of Acidic Calcium Phosphate Cements
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The gold standard for bone replacement today, autologous bone, suffers from several disadvantages, such as the increased risk of infection due to the need for two surgeries. Degradable synthetic materials with properties similar to bone, such as calcium phosphate cements, are a promising alternative. Calcium phosphate cements are suited for a limited amount of applications and improving their physical properties could extend their use into areas previously not considered possible. For example, cement with increased strength could be used as load bearing support in selected applications. The focus of this thesis is, therefore, on how the physical properties of acidic calcium phosphate cements (brushite cements) are affected by compositional variations, with the ultimate aim of making it possible to formulate brushite cements with desired properties.

In this thesis a method to measure the porosity of a cement was developed. This method is advantageous over existing methods as it is easy to use, requiring no advanced equipment. A model estimating the porosity of the hardened cement from the initial chemical composition was further formulated and the accuracy affirmed. Utilization of this model allows the porosity to be optimized by calculations rather than extensive laboratory work. The effect on strength and porosity of several compositional variations were also assessed and it was found that the optimal composition to achieve a high strength was: monocalcium phosphate particles in sizes <75µm, 10 mol% excess of beta-tricalcium phosphate, 1 wt% disodium dihydrogen pyrophosphate, and 0.5 M citric acid in a liquid-to-powder ratio of 0.22 ml/g. This composition gave the highest compressive strength historically measured for this type of cement, i.e., 74.4 (±10.7) MPa. Although such a high strength may not be necessary for all applications, it allows for the use of brushite cements in new applications. Furthermore, a high strength of the bulk allows for alterations to the cement that cause a decrease in strength. One application is fast degrading materials, allowing rapid bone ingrowth. A fast degradation is obtained with a high macroporosity, which would reduce strength. The high strength composition was therefore utilized to achieve brushite cement with a high macroporosity.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2014. 73 p.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1195
National Category
Biomaterials Science Ceramics Medical Materials
urn:nbn:se:uu:diva-233637 (URN)978-91-554-9081-2 (ISBN)
Public defence
2014-12-05, Polhemsalen, Ångströmlaboratoriet, Uppsala, 09:15 (English)
EU, FP7, Seventh Framework ProgrammeSwedish Research Council
Available from: 2014-11-14 Created: 2014-10-07 Last updated: 2015-02-03

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