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Brushite foams - the effect of Tween® 80 and Pluronic® F-127 on foam porosity and mechanical properties
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)
Technical University of Catalonia, Spain.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)
Technical University of Catalonia, Spain.
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(English)In: Journal of Biomedical Materials Research. Part B - Applied biomaterials, ISSN 1552-4973, E-ISSN 1552-4981Article in journal (Other academic) Submitted
Abstract [en]

Resorbable calcium phosphate  based bone void  fillers  should work as  temporary  templates  for new bone formation. The incorporation of macropores with sizes of 100 -300 µm has been shown to  increase the resorption rate of the implant and speed up bone ingrowth. In this work, macroporous brushite cements were fabricated through foaming of the cement paste, utilizing two different synthetic surfactants,  Tween® 80 and Pluronic® F-127.  The macropores formed in the Pluronic  samples  were  both smaller and less  homogeneously  distributed  compared with  the pores formed in the Tween samples. The porosity and compressive strength were comparable to previously developed hydroxyapatite foams. The cement foam containing Tween, 0.5 M citric acid in the liquid, 1 mass% of disodium dihydrogen pyrophosphate mixed in the powder and a liquid to powder ratio  of 0.43  mL/g,  showed  the highest  porosity values  (76  %  total and  56  % macroporosity), while the compressive strength was higher than 1 MPa, i.e. the hardened cement could be handled without rupture of the foamed structure. The investigated brushite foams show potential for future clinical use, both as bone void fillers and as scaffolds for in vitro bone regeneration.

Keyword [en]
Brushite, foam, Tween® 80, Pluronic® F-127, porosity, strength, setting time
National Category
Medical Materials Ceramics
Identifiers
URN: urn:nbn:se:uu:diva-233630OAI: oai:DiVA.org:uu-233630DiVA: diva2:753204
Funder
EU, FP7, Seventh Framework ProgrammeThe Swedish Foundation for International Cooperation in Research and Higher Education (STINT), GA IG2011-2047Swedish Research Council, GA 621- 2011-6258Swedish Research Council, GA 621-2011-3399
Available from: 2014-10-07 Created: 2014-10-07 Last updated: 2017-12-05
In thesis
1. Physical Properties of Acidic Calcium Phosphate Cements
Open this publication in new window or tab >>Physical Properties of Acidic Calcium Phosphate Cements
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The gold standard for bone replacement today, autologous bone, suffers from several disadvantages, such as the increased risk of infection due to the need for two surgeries. Degradable synthetic materials with properties similar to bone, such as calcium phosphate cements, are a promising alternative. Calcium phosphate cements are suited for a limited amount of applications and improving their physical properties could extend their use into areas previously not considered possible. For example, cement with increased strength could be used as load bearing support in selected applications. The focus of this thesis is, therefore, on how the physical properties of acidic calcium phosphate cements (brushite cements) are affected by compositional variations, with the ultimate aim of making it possible to formulate brushite cements with desired properties.

In this thesis a method to measure the porosity of a cement was developed. This method is advantageous over existing methods as it is easy to use, requiring no advanced equipment. A model estimating the porosity of the hardened cement from the initial chemical composition was further formulated and the accuracy affirmed. Utilization of this model allows the porosity to be optimized by calculations rather than extensive laboratory work. The effect on strength and porosity of several compositional variations were also assessed and it was found that the optimal composition to achieve a high strength was: monocalcium phosphate particles in sizes <75µm, 10 mol% excess of beta-tricalcium phosphate, 1 wt% disodium dihydrogen pyrophosphate, and 0.5 M citric acid in a liquid-to-powder ratio of 0.22 ml/g. This composition gave the highest compressive strength historically measured for this type of cement, i.e., 74.4 (±10.7) MPa. Although such a high strength may not be necessary for all applications, it allows for the use of brushite cements in new applications. Furthermore, a high strength of the bulk allows for alterations to the cement that cause a decrease in strength. One application is fast degrading materials, allowing rapid bone ingrowth. A fast degradation is obtained with a high macroporosity, which would reduce strength. The high strength composition was therefore utilized to achieve brushite cement with a high macroporosity.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2014. 73 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1195
National Category
Biomaterials Science Ceramics Medical Materials
Identifiers
urn:nbn:se:uu:diva-233637 (URN)978-91-554-9081-2 (ISBN)
Public defence
2014-12-05, Polhemsalen, Ångströmlaboratoriet, Uppsala, 09:15 (English)
Opponent
Supervisors
Funder
EU, FP7, Seventh Framework ProgrammeSwedish Research Council
Available from: 2014-11-14 Created: 2014-10-07 Last updated: 2015-02-03

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Unosson, JohannaEngqvist, Håkan

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