Brushite foams - the effect of Tween® 80 and Pluronic® F-127 on foam porosity and mechanical properties
(English)In: Journal of Biomedical Materials Research. Part B - Applied biomaterials, ISSN 1552-4973, E-ISSN 1552-4981Article in journal (Other academic) Submitted
Resorbable calcium phosphate based bone void fillers should work as temporary templates for new bone formation. The incorporation of macropores with sizes of 100 -300 µm has been shown to increase the resorption rate of the implant and speed up bone ingrowth. In this work, macroporous brushite cements were fabricated through foaming of the cement paste, utilizing two different synthetic surfactants, Tween® 80 and Pluronic® F-127. The macropores formed in the Pluronic samples were both smaller and less homogeneously distributed compared with the pores formed in the Tween samples. The porosity and compressive strength were comparable to previously developed hydroxyapatite foams. The cement foam containing Tween, 0.5 M citric acid in the liquid, 1 mass% of disodium dihydrogen pyrophosphate mixed in the powder and a liquid to powder ratio of 0.43 mL/g, showed the highest porosity values (76 % total and 56 % macroporosity), while the compressive strength was higher than 1 MPa, i.e. the hardened cement could be handled without rupture of the foamed structure. The investigated brushite foams show potential for future clinical use, both as bone void fillers and as scaffolds for in vitro bone regeneration.
Brushite, foam, Tween® 80, Pluronic® F-127, porosity, strength, setting time
Medical Materials Ceramics
IdentifiersURN: urn:nbn:se:uu:diva-233630OAI: oai:DiVA.org:uu-233630DiVA: diva2:753204
FunderEU, FP7, Seventh Framework ProgrammeThe Swedish Foundation for International Cooperation in Research and Higher Education (STINT), GA IG2011-2047Swedish Research Council, GA 621- 2011-6258Swedish Research Council, GA 621-2011-3399