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Genome-wide association studies of obesity and metabolic syndrome
Dept. of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID iD: 0000-0003-2071-5866
Dept. of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID iD: 0000-0003-2256-6972
2014 (English)In: Molecular and Cellular Endocrinology, ISSN 0303-7207, E-ISSN 1872-8057, Vol. 382, no 1, 740-757 p.Article in journal (Refereed) Published
Abstract [en]

Until just a few years ago, the genetic determinants of obesity and metabolic syndrome were largely unknown, with the exception of a few forms of monogenic extreme obesity. Since genome-wide association studies (GWAS) became available, large advances have been made. The first single nucleotide polymorphism robustly associated with increased body mass index (BMI) was in 2007 mapped to a gene with for the time unknown function. This gene, now known as fat mass and obesity associated (FTO) has been repeatedly replicated in several ethnicities and is affecting obesity by regulating appetite. Since the first report from a GWAS of obesity, an increasing number of markers have been shown to be associated with BMI, other measures of obesity or fat distribution and metabolic syndrome. This systematic review of obesity GWAS will summarize genome-wide significant findings for obesity and metabolic syndrome and briefly give a few suggestions of what is to be expected in the next few years.

Place, publisher, year, edition, pages
2014. Vol. 382, no 1, 740-757 p.
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Medical Genetics
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URN: urn:nbn:se:uu:diva-233665DOI: 10.1016/j.mce.2012.08.018PubMedID: 22963884OAI: oai:DiVA.org:uu-233665DiVA: diva2:753429
Available from: 2014-10-07 Created: 2014-10-07 Last updated: 2017-12-05Bibliographically approved

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Fall, ToveIngelsson, Erik

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