uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A cis-Regulatory Mutation of PDSS2 Causes Silky-Feather in Chickens
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Show others and affiliations
2014 (English)In: PLOS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 10, no 8, e1004576- p.Article in journal (Refereed) Published
Abstract [en]

Silky-feather has been selected and fixed in some breeds due to its unique appearance. This phenotype is caused by a single recessive gene (hookless, h). Here we map the silky-feather locus to chromosome 3 by linkage analysis and subsequently fine-map it to an 18.9 kb interval using the identical by descent (IBD) method. Further analysis reveals that a C to G transversion located upstream of the prenyl (decaprenyl) diphosphate synthase, subunit 2 (PDSS2) gene is causing silky-feather. All silky-feather birds are homozygous for the G allele. The silky-feather mutation significantly decreases the expression of PDSS2 during feather development in vivo. Consistent with the regulatory effect, the C to G transversion is shown to remarkably reduce PDSS2 promoter activity in vitro. We report a new example of feather structure variation associated with a spontaneous mutation and provide new insight into the PDSS2 function.

Place, publisher, year, edition, pages
2014. Vol. 10, no 8, e1004576- p.
National Category
Medical Genetics Basic Medicine
Identifiers
URN: urn:nbn:se:uu:diva-234208DOI: 10.1371/journal.pgen.1004576ISI: 000341577800054OAI: oai:DiVA.org:uu-234208DiVA: diva2:755940
Available from: 2014-10-15 Created: 2014-10-15 Last updated: 2017-12-05Bibliographically approved

Open Access in DiVA

fulltext(3976 kB)295 downloads
File information
File name FULLTEXT01.pdfFile size 3976 kBChecksum SHA-512
7175a94f3e92c7290ad02a387cd742cad554c37bb4f26ebf7946a9d6d52a23072cf7ef4360b68ef67687244c84d81857a59f4890be9af936577ba38ff5138227
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Rubin, Carl-JohanAndersson, Leif

Search in DiVA

By author/editor
Rubin, Carl-JohanAndersson, Leif
By organisation
Department of Medical Biochemistry and MicrobiologyScience for Life Laboratory, SciLifeLab
In the same journal
PLOS Genetics
Medical GeneticsBasic Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 295 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 824 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf