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Procalcitonin levels in community-acquired pneumonia: correlation with aetiology and severity
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
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2014 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, E-ISSN 1651-1980, Vol. 46, no 11, 787-791 p.Article in journal (Refereed) Published
Abstract [en]

We studied procalcitonin (PCT) levels at hospital admittance and their association with aetiology and severity in patients with community-acquired pneumonia (CAP). Median PCT concentrations were higher in bacteraemic patients than in those without bacteraemia (6.11 μg/L vs 0.34 μg/L, p = 0.0002), in patients with non-bacteraemic pneumococcal aetiology than in those infected with other classic bacteria (1.18 vs 0.18, p = 0.038), and in patients with pneumococcal as compared with viral aetiology (2.43 vs 0.24, p = 0.017). When aetiology, bacteraemia and severity according to the pneumonia severity index (PSI) were included in logistic regression analyses with PCT > 0.5 as a dependent variable, the odds ratio (OR) for non-bacteraemic pneumococcal aetiology was 5.7 (p = 0.008) and 3.0 ( p = 0.1) for PSI 4-5. A separate analysis for bacteraemia and PSI 4-5 showed an OR of 17.5 (p = 0.008) and 2.7 (p = 0.092), respectively. In CAP patients, high PCT seems to be a good marker for invasive disease and pneumococcal aetiology. As a predictor of severity it appears to be less important.

Place, publisher, year, edition, pages
2014. Vol. 46, no 11, 787-791 p.
National Category
Infectious Medicine
URN: urn:nbn:se:uu:diva-234311DOI: 10.3109/00365548.2014.945955ISI: 000343977500008PubMedID: 25195651OAI: oai:DiVA.org:uu-234311DiVA: diva2:756073
Available from: 2014-10-16 Created: 2014-10-16 Last updated: 2014-12-15Bibliographically approved

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