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Resuscitation with amiodarone increases survival after hemorrhage and ventricular fibrillation in pigs
Department of Operative and Intensive Care Medicine, Hallands Hospital Halmstad, Halmstad, Sweden.ORCID iD: frank@zoerner.org
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2014 (English)In: Journal of Trauma and Acute Care Surgery, ISSN 2163-0755, E-ISSN 2163-0763, Vol. 76, no 6, 1402-1408 p.Article in journal (Refereed) Published
Abstract [en]


The aim of this experimental study was to compare survival and hemodynamic effects of a low-dose amiodarone and vasopressin compared with vasopressin in hypovolemic cardiac arrest model in piglets.


Eighteen anesthetized male piglets (with a weight of 25.3 [1.8] kg) were bled approximately 30% of the total blood volume via the femoral artery to a mean arterial blood pressure of 35 mm Hg in a 15-minute period. Afterward, the piglets were subjected to 4 minutes of untreated ventricular fibrillation followed by 11 minutes of open-chest cardiopulmonary resuscitation. At 5 minutes, circulatory arrest amiodarone 1 mg/kg was intravenously administered in the amiodarone group (n = 9), while the control group received the same amount of saline (n = 9). At the same time, all piglets received vasopressin 0.4 U/kg intravenously administered and hypertonic-hyperoncotic solution 3-mL/kg infusion for 20 minutes. Internal defibrillation was attempted from 7 minutes of cardiac arrest to achieve restoration of spontaneous circulation. The experiment was terminated 3 hours after resuscitation.


Three-hour survival was greater in the amiodarone group (p = 0.02). After the successful resuscitation, the amiodarone group piglets had significantly lower heart rate as well as greater systolic, diastolic, and mean arterial pressure. Troponin I plasma concentrations were lower and urine output was greater in the amiodarone group.


Combined resuscitation with amiodarone and vasopressin after hemorrhagic circulatory arrest resulted in greater 3-hour survival, better preserved hemodynamic parameters, and smaller myocardial injury compared with resuscitation with vasopressin only.

Place, publisher, year, edition, pages
2014. Vol. 76, no 6, 1402-1408 p.
National Category
Anesthesiology and Intensive Care
Research subject
Medical Science
URN: urn:nbn:se:uu:diva-234505DOI: 10.1097/TA.0000000000000243OAI: oai:DiVA.org:uu-234505DiVA: diva2:756910
Novel Interventions in Cardiac Arrest
Available from: 2014-10-20 Created: 2014-10-20 Last updated: 2014-10-28Bibliographically approved

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