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Changes in adipose tissue mRNA expression due to perinatal exposure to bisphenol A in rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
2014 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Bisphenol A (BPA) is an estrogen receptor binding chemical, widely used in the plastics industry, and as such commonly encountered from plastic containers etc. Even at very low doses, BPA is believed to induce obesity and to have various endocrine disruptive effects. The purpose of this study was to determine possible gene expression changes in gonadal and inguinal adipose tissue from rats perinatally exposed to BPA. The method used was quantitative real-time PCR, and genes found to be up-regulated were PLZF, adiponectin, RXRa and Tcf21, while down-regulated genes were PPARγ, Tmem26, EsR1, Resistin, LPL, Chemerin, Serpina6, TFAM and Ahr. This is so far largely unsupported by other studies, and more research is needed.

Place, publisher, year, edition, pages
Keyword [en]
Obesity, endocrine disruptor, metabolism, PPARγ, estrogen receptors
National Category
Biomedical Laboratory Science/Technology
URN: urn:nbn:se:uu:diva-235115OAI: oai:DiVA.org:uu-235115DiVA: diva2:758986
Educational program
Biomedical Laboratory Science Programme
Available from: 2014-11-27 Created: 2014-10-28 Last updated: 2014-11-27Bibliographically approved

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