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Infections in status epilepticus: A retrospective 5-year cohort study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
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2014 (English)In: Seizure, ISSN 1059-1311, E-ISSN 1532-2688, Vol. 23, no 8, 603-606 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: Status epilepticus (SE) has attracted renewed interest lately, and efforts are made to optimize every treatment stage. For refractory SE, optimal supporting care involves mechanical ventilation and intensive care unit (ICU) admission. Infections often complicate SE and recently a single-centre observational study demonstrated an association between infections and poor short-term outcome of SE in a cohort of severely ill patients. We have here attempted to replicate those findings in a different cohort. Method: We performed a retrospective observational study and included all patients with a diagnosis of SE during 2008-2012 at a Swedish tertiary referral centre. Results: The cohort consisted of 103 patients (53% female, 47% male, median age 62 years, range 19-87 years). In house mortality was less than 2 and 70% of the patients' were discharged home. The most common aetiologies of SE were uncontrolled epilepsy (37%) and brain tumours (16%). A total of 39 patients suffered infections during their stay. Presence of infection was associated with mechanical ventilation (OR 3.344, 95% Cl 1.44-7.79) as well as not being discharged home (OR2.705, 95% Cl 1.14-6.44), and duration of SE was significantly longer in patients with infection (median 1 day vs. 2.5 days, p < 0.001). Conclusion: We conclude that the previously described association between infections, a longer SE duration, and an unfavourable outcome of SE seems valid also in SE of less severe aetiology.  

Place, publisher, year, edition, pages
2014. Vol. 23, no 8, 603-606 p.
Keyword [en]
Status epilepticus, Infection, ICU
National Category
Neurosciences Neurology
Identifiers
URN: urn:nbn:se:uu:diva-235095DOI: 10.1016/j.seizure.2014.04.012ISI: 000341558600004OAI: oai:DiVA.org:uu-235095DiVA: diva2:759090
Available from: 2014-10-29 Created: 2014-10-28 Last updated: 2017-12-05Bibliographically approved

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Zelano, JohanKumlien, Eva

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