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Effect of cardiovascular drugs on mortality in atrial fibrillation and chronic heart failure
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
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2014 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, Vol. 48, no 5, 291-298 p.Article in journal (Refereed) Published
Abstract [en]

Objectives. To study mortality rates among men and women with atrial fibrillation (AF) and concomitant chronic heart failure (CHF) prescribed different classes of cardiovascular drugs in primary health care. Design. A cohort of men (n = 1159) and women (n = 1155) aged 45 years or above and diagnosed with both AF and CHF from patient records from 75 primary care centers in Sweden were included in the study. Regression models with mortality as the outcome were used, with adjustment for a propensity score comprising age, cardiovascular co-morbidities, education, marital status, and pharmacotherapy. We analysed using Cox regression with hazard ratio (HR), and Laplace regression with years until 10% of the patients had died, with 95% confi dence intervals (95% CI). Independent variables were prescribed cardiovascular drugs. Results. Individuals prescribed anticoagulants versus no treatment gained 1.95 years (95% CI 0.47-3.43), anticoagulants versus antiplatelets 1.26 years (95% CI 0.42-2.10), calcium channel blockers 1.17 years (95% CI 0.21-2.14), and statins 1.49 years (95% CI 0.39-2.59). Among patients 80 years or above no significant effect by anticoagulants was seen, HR 0.73 (95% CI 0.43-1.23). Conclusions. Our findings suggest that life may be prolonged in patients with AF and concomitant CHF in primary care prescribed anticoagulants, calcium channel blockers, and statins.

Place, publisher, year, edition, pages
2014. Vol. 48, no 5, 291-298 p.
Keyword [en]
antithrombotic drugs, follow-up, gender, mortality, pharmacotherapy, propensity score, statins
National Category
Cardiac and Cardiovascular Systems
URN: urn:nbn:se:uu:diva-235319DOI: 10.3109/14017431.2014.941002ISI: 000342346300007OAI: oai:DiVA.org:uu-235319DiVA: diva2:761079
Available from: 2014-11-05 Created: 2014-10-30 Last updated: 2014-11-05Bibliographically approved

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Carlsson, Axel C.
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Molecular epidemiologyScience for Life Laboratory, SciLifeLab
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