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A Case Report of Improved Metabolic Control After Conversion From Everolimus to Cyclosporin A: Role of Adipose Tissue Mechanisms?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
2014 (English)In: Transplantation Proceedings, ISSN 0041-1345, E-ISSN 1873-2623, Vol. 46, no 7, 2377-2380 p.Article in journal (Refereed) Published
Abstract [en]

Background. New-onset diabetes after transplantation is associated with an increase in risk of graft failure, cardiovascular disease, and mortality. Therefore, it compromises the overall beneficial outcome of organ transplantation. Case Report. A patient with new-onset diabetes after renal transplantation showed glucose and lipid metabolism improvements after switching immunosuppressant from everolimus to cyclosporin A. A subcutaneous adipose tissue biopsy displayed changes in gene and protein expression that could contribute to the clinical improvement of hyperglycemia and dyslipidemia.

Place, publisher, year, edition, pages
2014. Vol. 46, no 7, 2377-2380 p.
National Category
Immunology in the medical area Surgery
Identifiers
URN: urn:nbn:se:uu:diva-235513DOI: 10.1016/j.transproceed.2014.02.018ISI: 000342397500047OAI: oai:DiVA.org:uu-235513DiVA: diva2:761184
Conference
37th Congress of the Italian-Transplantation-Society (SITO), OCT 24-26, 2013, Bari, ITALY
Available from: 2014-11-05 Created: 2014-11-05 Last updated: 2017-12-05Bibliographically approved

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Pereira, Maria J.Eriksson, Jan W.

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