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The role and regulation of complement activation as part of the thromboinflammation elicited in cell therapies
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
2014 (English)In: Molecular Immunology, ISSN 0161-5890, E-ISSN 1872-9142, Vol. 61, no 2, 185-190 p.Article, review/survey (Refereed) Published
Abstract [en]

Cell therapies in which the cells come into direct contact with blood and other body fluids are emerging treatment procedures for patients with various diseases, such as diabetes mellitus, liver insufficiency, and graft-versus-host disease. However, despite recent progress, these procedures are associated with tissue loss caused by thromboinflammatory reactions. These deleterious reactions involve the activation of the complement and coagulation cascades and platelet and leukocyte activation, ultimately resulting in clot formation and damage to the implanted cells. In this concept review, we discuss the basic mechanisms underlying the thrombininflammatory process, with special reference to the engagement of complement and emerging strategies for the therapeutic regulation of these reactions that include the use of selective systemic inhibitors and various procedures to coat the surfaces of the cells. The coating procedures may also be applied to other treatment modalities in which similar mechanisms are involved, including whole organ transplantation, treatment with biomaterials in contact with blood, and extracorporeal procedures.

Place, publisher, year, edition, pages
2014. Vol. 61, no 2, 185-190 p.
Keyword [en]
Thromboinflammation, Instant blood-mediated inflammatory reaction (IBMIR), Contact system, Complement, Coagulation, Platelets
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-235586DOI: 10.1016/j.molimm.2014.06.009ISI: 000342265300016OAI: oai:DiVA.org:uu-235586DiVA: diva2:761430
Available from: 2014-11-06 Created: 2014-11-06 Last updated: 2017-12-05Bibliographically approved

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Nilsson, BoTeramura, YujiEkdahl, Kristina N.

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