Long-term administration of vasopressin can cause Meniere's disease in mice
2014 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 134, no 10, 990-1004 p.Article in journal (Refereed) Published
Conclusion: A new murine model of Meniere's disease has been developed, based on long-term administration of vasopressin. Induction of vestibular dysfunction in the present animal model can cause additional stress, by reducing inner ear blood flow. Latanoprost, a selective agonist for the FP prostanoid receptor, may become a new remedy for Meniere's disease. Objective: The purpose of this study was to develop a more suitable animal model, with a closer resemblance to the pathophysiological process in Meniere's disease. Methods: Adult CBA/J or ICR mice were treated by subcutaneous injection of vasopressin for 5 days up to 8 weeks. Morphological analyses were performed of the cochlea, vestibular end organs and endolymphatic sac. The effect of latanoprost on the development of endolymphatic hydrops was also examined. Results: All experimental animals showed mild to moderate endolymphatic hydrops, increasing in severity as the vasopressin treatment was prolonged. Animals treated with vasopressin for 8 weeks showed severe endolymphatic hydrops with partial loss of outer hair cells and spiral ganglion cells. These animals also had a reversible vestibular dysfunction following intratympanic injection of epinephrine. Latanoprost inhibited the development of endolymphatic hydrops caused by vasopressin.
Place, publisher, year, edition, pages
2014. Vol. 134, no 10, 990-1004 p.
Endolymphatic hydrops, vestibular dysfunction, latanoprost
IdentifiersURN: urn:nbn:se:uu:diva-235303DOI: 10.3109/00016489.2014.902989ISI: 000342204900002PubMedID: 25131393OAI: oai:DiVA.org:uu-235303DiVA: diva2:761503