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Long-term administration of vasopressin can cause Meniere's disease in mice
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
2014 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 134, no 10, 990-1004 p.Article in journal (Refereed) Published
Abstract [en]

Conclusion: A new murine model of Meniere's disease has been developed, based on long-term administration of vasopressin. Induction of vestibular dysfunction in the present animal model can cause additional stress, by reducing inner ear blood flow. Latanoprost, a selective agonist for the FP prostanoid receptor, may become a new remedy for Meniere's disease. Objective: The purpose of this study was to develop a more suitable animal model, with a closer resemblance to the pathophysiological process in Meniere's disease. Methods: Adult CBA/J or ICR mice were treated by subcutaneous injection of vasopressin for 5 days up to 8 weeks. Morphological analyses were performed of the cochlea, vestibular end organs and endolymphatic sac. The effect of latanoprost on the development of endolymphatic hydrops was also examined. Results: All experimental animals showed mild to moderate endolymphatic hydrops, increasing in severity as the vasopressin treatment was prolonged. Animals treated with vasopressin for 8 weeks showed severe endolymphatic hydrops with partial loss of outer hair cells and spiral ganglion cells. These animals also had a reversible vestibular dysfunction following intratympanic injection of epinephrine. Latanoprost inhibited the development of endolymphatic hydrops caused by vasopressin.

Place, publisher, year, edition, pages
2014. Vol. 134, no 10, 990-1004 p.
Keyword [en]
Endolymphatic hydrops, vestibular dysfunction, latanoprost
National Category
Otorhinolaryngology
Identifiers
URN: urn:nbn:se:uu:diva-235303DOI: 10.3109/00016489.2014.902989ISI: 000342204900002PubMedID: 25131393OAI: oai:DiVA.org:uu-235303DiVA: diva2:761503
Available from: 2014-11-06 Created: 2014-10-30 Last updated: 2017-12-05Bibliographically approved

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Anniko, Matti

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