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Saralasin and Sarile Are AT2 Receptor Agonists
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
2014 (English)In: ACS Medicinal Chemistry Letters, ISSN 1948-5875, E-ISSN 1948-5875, Vol. 5, no 10, 1129-1132 p.Article in journal (Refereed) Published
Abstract [en]

Saralasin and sarile, extensively studied over the past 40 years as angiotensin II (Ang II) receptor blockers, induce neurite outgrowth in a NG108-15 cell assay to a similar extent as the endogenous Ang II. In their undifferentiated state, these cells express mainly the AT2 receptor. The neurite outgrowth was inhibited by preincubation with the AT2 receptor selective antagonist PD 123,319, which suggests that the observed outgrowth was mediated by the AT2 receptor. Neither saralasin nor sarile reduced the neurite outgrowth induced by Ang II proving that the two octapeptides do not act as antagonists at the AT2 receptor and may be considered as AT2 receptor agonists.

Place, publisher, year, edition, pages
2014. Vol. 5, no 10, 1129-1132 p.
National Category
Pharmaceutical Sciences Medicinal Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-235670DOI: 10.1021/ml500278gISI: 000343016700012PubMedID: 25313325OAI: oai:DiVA.org:uu-235670DiVA: diva2:761592
Available from: 2014-11-07 Created: 2014-11-07 Last updated: 2017-12-05Bibliographically approved

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