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Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemical endocrinology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
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2014 (English)In: European Journal of Medical Research, ISSN 0949-2321, E-ISSN 2047-783X, Vol. 19, 61- p.Article in journal (Refereed) Published
Abstract [en]

Background: Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels.

Methods: Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA.

Results: Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group.

Conclusion: Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing.

Place, publisher, year, edition, pages
2014. Vol. 19, 61- p.
National Category
Surgery
Identifiers
URN: urn:nbn:se:uu:diva-235764DOI: 10.1186/s40001-014-0061-9ISI: 000345944200001PubMedID: 25380724OAI: oai:DiVA.org:uu-235764DiVA: diva2:761880
Available from: 2014-11-09 Created: 2014-11-09 Last updated: 2017-12-05Bibliographically approved

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Åkerfeldt, TorbjörnGunningberg, LenaLeo Swenne, ChristineRonquist, GöranLarsson, Anders

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