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Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain
Karolinska Insitutet, CMB.
Karolinska Insitutet, CMB.
Karolinska Insitutet, CMB.
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2014 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 159, no 4, 766-774 p.Article in journal (Refereed) Published
Abstract [en]

The myelination of axons by oligodendrocytes has been suggested to be modulated by experience, which could mediate neural plasticity by optimizing the performance of the circuitry. We have assessed the dynamics of oligodendrocyte generation and myelination in the human brain. The number of oligodendrocytes in the corpus callosum is established in childhood and remains stable after that. Analysis of the integration of nuclear bomb test-derived 14C revealed that myelin is exchanged at a high rate, whereas the oligodendrocyte population in white matter is remarkably stable in humans, with an annual exchange of 1/300 oligodendrocytes. We conclude that oligodendrocyte turnover contributes minimally to myelin remodeling in human white matter and that this instead may be carried out by mature oligodendrocytes, which may facilitate rapid neural plasticity.

Place, publisher, year, edition, pages
Maryland Heights: Elsevier, 2014. Vol. 159, no 4, 766-774 p.
Keyword [en]
Neurogenesis, oligodendrocyte, brain, cell renewal, bomb-peak, white matter, myelin
National Category
Biophysics Cell Biology Accelerator Physics and Instrumentation Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Research subject
Biology with specialization in Molecular Cell Biology; Cell Research; Physics with specialization in Biophysics
Identifiers
URN: urn:nbn:se:uu:diva-235867DOI: 10.1016/j.cell.2014.10.011ISI: 000344522000010PubMedID: 25417154OAI: oai:DiVA.org:uu-235867DiVA: diva2:762427
Projects
The Human Regenerative Map, Linné Project 2008-2018
Funder
Swedish Research Council
Available from: 2014-11-11 Created: 2014-11-11 Last updated: 2017-12-05Bibliographically approved

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Salehpour, MehranPossnert, Göran

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