uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Effects of Ethinylestradiol and the fungicide Prochloraz on metamorphosis and thyroid gland morphology in Rana temporaria.
2010 (English)In: The Open Zoology Journal, Vol. 3, 7-16 p.Article in journal (Other academic) Published
Abstract [en]

Several environmental xenobiotics have been found to affect the metamorphosis of amphibians. In this study we exposed tadpoles of the Common frog Rana temporaria from hatching to metamorphosis to two known endocrine disruptors, the estrogenic pharmaceutical 17􀀁-ethinylestradiol and the antiandrogenic/antiestrogenic fungicide Prochloraz to determine their effect on 1) days to metamorphosis and size at metamorphosis, 2) body concentrations of triiodothyronine (T3) and corticosterone, and 3) thyroid morphology. We found effects of both compounds on each of these response variables. A low dose of prochloraz (115 μg/l) and all doses of ethinylestradiol also caused a delay in metamorphosis. T3 levels were elevated in metamorphs exposed to high concentration of prochloraz (252 μg/l) but the group showed a delay in metamorphosis. A low dose of prochloraz (115 μg/l) and all doses of ethinylestradiol also caused a delay in metamorphosis but no changes in T3 levels. The delayed metamorphs weighed more than controls. Thyroid histology revealed significant differences in the high prochloraz exposure group only. Ethinylestradiol and prochloraz,however not in environmentally relevant doses, may therefore impact the thyroid axis, and may cause other sublethal effects especially in combination with other stressors likely encountered.

Place, publisher, year, edition, pages
2010. Vol. 3, 7-16 p.
Keyword [en]
Endocrine disruptors, Ethinylestradiol, Metamorphosis, Prochloraz, Rana temporaria, Thyroid gland
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-236077OAI: oai:DiVA.org:uu-236077DiVA: diva2:762680
Available from: 2014-11-12 Created: 2014-11-12 Last updated: 2014-11-12

Open Access in DiVA

No full text

Authority records BETA

Brande-Lavridsen, Nanna

Search in DiVA

By author/editor
Brande-Lavridsen, Nanna
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 353 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf