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Copper-mediated isotopic exchange between [125I]iodide and bis(triethylammonium) undecahydro-12-iodo-closo-dodecaborate in aqueous media
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. (BMS)ORCID iD: 0000-0001-6120-2683
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2004 (English)In: Journal of Radioanalytical and Nuclear Chemistry, ISSN 0236-5731, E-ISSN 1588-2780, Vol. 260, no 2, 295-299 p.Article in journal (Refereed) Published
Abstract [en]

Derivatives of dodecahydro-closo-dodecaborate(2-) anion were proposed as boron-rich compounds for boron-neutron capture therapy (BNCT) of malignant tumours. Labeling of such tumour-targeting compounds with radioisotopes would facilitate the investigation of their pharmacokinetics and help to optimize patient treatment protocols. Earlier, we reported the feasibility of labeling of closo-dodecaborate(2-) by isotopic exchange in molten acetamide. In this study, the feasibility of low-temperature isotopic exchange in the system [125I]iodide - bis(triethylammonium) undecahydro-12-iodo-closo-dodecaborate was investigated. Our attempts to perform the exchange in solvents such as methylene chloride, acetone and acetonitrile in the presence of phase-transfer catalysts were unsuccessful. However, copper mediated exchange in aqueous media was possible. Isotopic exchange of triethylammonium undecahydro-12-iodo-closo-dodecaborate provided a 90-95% labeling yield after heating for three and half hours at 100 °C.

Place, publisher, year, edition, pages
2004. Vol. 260, no 2, 295-299 p.
National Category
Organic Chemistry
URN: urn:nbn:se:uu:diva-48483DOI: 10.1023/B:JRNC.0000027099.63853.ccOAI: oai:DiVA.org:uu-48483DiVA: diva2:76389
Available from: 2006-05-17 Created: 2006-05-17 Last updated: 2015-03-24Bibliographically approved

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Orlova, AnnaTolmachev, Vladimir
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Department of ChemistryDepartment of Oncology, Radiology and Clinical Immunology
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