Copper-mediated isotopic exchange between [125I]iodide and bis(triethylammonium) undecahydro-12-iodo-closo-dodecaborate in aqueous media
2004 (English)In: Journal of Radioanalytical and Nuclear Chemistry, ISSN 0236-5731, E-ISSN 1588-2780, Vol. 260, no 2, 295-299 p.Article in journal (Refereed) Published
Derivatives of dodecahydro-closo-dodecaborate(2-) anion were proposed as boron-rich compounds for boron-neutron capture therapy (BNCT) of malignant tumours. Labeling of such tumour-targeting compounds with radioisotopes would facilitate the investigation of their pharmacokinetics and help to optimize patient treatment protocols. Earlier, we reported the feasibility of labeling of closo-dodecaborate(2-) by isotopic exchange in molten acetamide. In this study, the feasibility of low-temperature isotopic exchange in the system [125I]iodide - bis(triethylammonium) undecahydro-12-iodo-closo-dodecaborate was investigated. Our attempts to perform the exchange in solvents such as methylene chloride, acetone and acetonitrile in the presence of phase-transfer catalysts were unsuccessful. However, copper mediated exchange in aqueous media was possible. Isotopic exchange of triethylammonium undecahydro-12-iodo-closo-dodecaborate provided a 90-95% labeling yield after heating for three and half hours at 100 °C.
Place, publisher, year, edition, pages
2004. Vol. 260, no 2, 295-299 p.
IdentifiersURN: urn:nbn:se:uu:diva-48483DOI: 10.1023/B:JRNC.0000027099.63853.ccOAI: oai:DiVA.org:uu-48483DiVA: diva2:76389