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Phenotype Standardization for Statin-Induced Myotoxicity
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2014 (English)In: Clinical Pharmacology and Therapeutics, ISSN 0009-9236, E-ISSN 1532-6535, Vol. 96, no 4, 470-476 p.Article, review/survey (Refereed) Published
Abstract [en]

Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.

Place, publisher, year, edition, pages
2014. Vol. 96, no 4, 470-476 p.
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Pharmacology and Toxicology
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URN: urn:nbn:se:uu:diva-236045DOI: 10.1038/clpt.2014.121ISI: 000342675400025OAI: oai:DiVA.org:uu-236045DiVA: diva2:764289
Available from: 2014-11-18 Created: 2014-11-12 Last updated: 2017-12-05Bibliographically approved

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