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Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
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2014 (English)In: International journal of experimental pathology (Print), ISSN 0959-9673, E-ISSN 1365-2613, Vol. 95, no 5, 309-320 p.Article, review/survey (Refereed) Published
Abstract [en]

Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease associated with interface hepatitis, raised plasma liver enzymes, the presence of autoantibodies and regulatory T-cell (Tregs) dysfunction. The clinical course is heterogeneous, manifested by a fulminant or indolent course. Although genetic predisposition is well accepted, the combination with currently undefined environmental factors is crucial for the development of the disease. Progress in the development of reliable animal models provides added understanding of the pathophysiology of AIH, and these will be very useful in evaluating potential therapeutics. It appears that artificially breaking tolerance in the liver is easy. However, maintaining this state of tolerance breakdown, to get chronic hepatitis, is difficult because liver immune homeostasis is strongly regulated by several immune response inhibitory mechanisms. For example, Tregs are crucial regulators in acute and chronic hepatitis, and C57BL/6 mice are most prone to experimental AIH. Immunization of C57BL/6 mice with liver (AIH) autoantigens (CYP2D6/FTCD or IL-4R) and the disturbance of liver regulatory mechanism(s), leading to experimental AIH, are likely to be most representative of human AIH pathology.

Place, publisher, year, edition, pages
2014. Vol. 95, no 5, 309-320 p.
Keyword [en]
CYP2D6, formiminotransferase cyclodeaminase, liver tolerance, mouse models Th17, tregs
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:uu:diva-236050DOI: 10.1111/iep.12090ISI: 000342773500001OAI: oai:DiVA.org:uu-236050DiVA: diva2:764304
Available from: 2014-11-18 Created: 2014-11-12 Last updated: 2014-11-18Bibliographically approved

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Heindryckx, Femke
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