uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Botulinum toxin B in the treatment of craniofacial hyperhidrosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
Show others and affiliations
2014 (English)In: Journal of the European Academy of Dermatology and Venereology, ISSN 0926-9959, E-ISSN 1468-3083, Vol. 28, no 10, 1313-1317 p.Article in journal (Refereed) Published
Abstract [en]

Background Hyperhidrosis affects up to 3% of the population and negatively affects patients' quality of life. Craniofacial hyperhidrosis is a common complaint which has been successfully treated with botulinum toxin B (Btx B) since 2004 at our hidrosis clinics. Objective To evaluate the safety and clinical effect of Btx B in craniofacial hyperhidrosis. Methods The dermatology life quality index (DLQI) was monitored before and after treatment in 38 patients with craniofacial hyperhidrosis. Sweating before and after treatment was monitored by measuring trans epidermal water loss and by collecting gravimetric data. Global Assessment of Therapy in a 5-grade scale was captured. Results DLQI scores were significantly improved at follow-up 2-4 weeks posttreatment and sweating was significantly reduced. DLQI scores before treatment were 13 +/- 1 (mean +/- SD) and posttreatment 5 +/- 1 which was highly statistically significant (P < 0.001). Sweating before treatment monitored with trans epidermal water loss was 52 +/- 31 g/m(2)/h which decreased to 18 +/- 7 g/m(2)/h (P < 0.001) posttreatment. Gravimetric data yielded a sweat rate of 0.07 +/- 0.08 mg/min at baseline, which consequently dropped to 0.02 +/- 0.05 mg/min (P < 0.05) posttreatment. Regarding the Global Assessment of Therapy 87% of the patients were satisfied (score 4-5) with the treatment result. In a 2-year follow-up, 74% returned for further treatments after a median time of 5 months. Side-effects were mild and most commonly reported was stiffness of the forehead and the eyebrows. Conclusions In this prospective, uncontrolled study Btx B seems to be both a safe and effective treatment in craniofacial hyperhidrosis improving quality of life and reducing extreme sweating.

Place, publisher, year, edition, pages
2014. Vol. 28, no 10, 1313-1317 p.
National Category
Dermatology and Venereal Diseases
URN: urn:nbn:se:uu:diva-236058DOI: 10.1111/jdv.12278ISI: 000343007900007PubMedID: 24118460OAI: oai:DiVA.org:uu-236058DiVA: diva2:764319
Available from: 2014-11-18 Created: 2014-11-12 Last updated: 2014-11-18Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Karlqvist, MattiasSwartling, Carl
By organisation
Dermatology and VenereologyCentre for Research and Development, Gävleborg
In the same journal
Journal of the European Academy of Dermatology and Venereology
Dermatology and Venereal Diseases

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 201 hits
ReferencesLink to record
Permanent link

Direct link