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Controlling Osteogenic Differentiation through Nanoporous Alumina
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
University of Texas at Arlington.
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2014 (English)In: Journal of Biomaterials and Nanobiotechnology, ISSN 2158-7027, E-ISSN 2158-7043, Vol. 5, no 2, 98-104 p.Article in journal (Refereed) Published
Abstract [en]

Nanotopographical features are found to have significant effects on bone behavior. In the presentstudy, nanoporous aluminas with different pore sizes (20, 100 and 200 nm in diameter), were eva-luated for their osteoinductive and drug eluting properties. W20-17 marrow stromal cells wereseeded on nanoporous alumina with and without the addition of BMP-2. Although cell prolifera-tion was not affected by pore size, osteogenic differentiation was 200 nm as compared to 20 and100 nm pores induced higher alkaline phosphatase activity (ALP) and osteocalcin expression le-vels, thus indicating osteoblastic differentiation. Cell morphology revealed that cells cultured on20 nm pores adopted a rounded shape, while larger pores (200 nm) elicited an elongated morpho-logy. Furthermore, ALP expression levels were consistently higher on BMP-2 loaded nanoporousalumina surfaces compared to unloaded surfaces, indicating that not only is nanoporous aluminaosteoinductive, but also has the potential to be used as a drug eluting bone-implant coating.

Place, publisher, year, edition, pages
2014. Vol. 5, no 2, 98-104 p.
National Category
Medical Materials
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URN: urn:nbn:se:uu:diva-236746DOI: 10.4236/jbnb.2014.52012OAI: oai:DiVA.org:uu-236746DiVA: diva2:765354
Available from: 2014-11-22 Created: 2014-11-22 Last updated: 2017-12-05Bibliographically approved

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Pujari-Palmer, ShiuliLind, ThomasXia, WeiKarlsson Ott, Marjam

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