One-Pot Synthesis of Keto Thioethers by Palladium/Gold-Catalyzed Click and Pinacol Reactions
2014 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 16, no 21, 5556-5559 p.Article in journal (Refereed) Published
An atom-efficient synthesis of keto thioethers was devised via tandem gold/palladium catalysis. The reaction proceeds through a regioselective thiol attack at the β-position of the alcohol, followed by an alkyl, aryl, or benzyl 1,2-shift. Both acyclic and cyclic systems were studied, in the latter case leading to the ring expansion of cyclic substrates.
Place, publisher, year, edition, pages
American Chemical Society (ACS), 2014. Vol. 16, no 21, 5556-5559 p.
Gold, Palladium, thioether, catalysis, synthesis
IdentifiersURN: urn:nbn:se:uu:diva-236857DOI: 10.1021/ol502553pISI: 000344635200013PubMedID: 25325145OAI: oai:DiVA.org:uu-236857DiVA: diva2:765716