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Determinants of uncontrolled asthma in a Swedish asthma population: cross-sectional observational study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
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2014 (English)In: European Clinical Respiratory Journal, ISSN 2001-8525, Vol. 1, 24109- p.Article in journal (Refereed) Published
Abstract [en]

Background: Asthma control is achieved in a low proportion of patients. The primary aim was to evaluate riskfactors for uncontrolled asthma. The secondary aim was to assess quality of life associated with asthmacontrol.

Methods: In a cross-sectional study, asthma patients aged 18Á75 were randomly selected from primary andsecondary health care centers. Postal questionnaires were sent to 1,675 patients and the response rate was71%. A total of 846 patients from primary and 341 patients from secondary care were evaluated. Data werecollected using a questionnaire and review of medical records. The questionnaire included questions aboutasthma control and a quality-of-life questionnaire, the mini-AQLQ, with four domains (symptoms, activitylimitation, emotional function, and environmental stimuli). The mean score for each domain and the overallscore were calculated. Asthma control was divided into three levels according to the GINA guidelines andpartly and uncontrolled asthma were combined into one group - poorly controlled asthma.

Results: Asthma control was achieved in 36% of the sample: 38% in primary and 29% in secondary care. Inprimary and secondary care, 35 and 45% had uncontrolled asthma, respectively. Risk factors for poorly con-trolled asthma were female sex [OR 1.31 (1.003Á1.70)], older age [OR 2.18 (1.28Á3.73)], lower educational level[OR 1.63 (1.14Á2.33)], and current smoking [OR 1.68 (1.16Á2.43)]. Older age and lower educational level re-mained statistically significantly associated with poorly controlled asthma when the analyses were limited to never-smokers. Depression was an independent risk factor for poorly controlled asthma in men [OR 3.44 (1.12Á10.54)].The mini-AQLQ scores and the mean overall score were significantly lower in uncontrolled asthma.

Conclusion: Risk factors for poorly controlled asthma were female sex, older age, low educational level, andsmoking. Uncontrolled asthma was significantly associated with lower quality of life.

Place, publisher, year, edition, pages
2014. Vol. 1, 24109- p.
National Category
Respiratory Medicine and Allergy
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URN: urn:nbn:se:uu:diva-236887DOI: 10.3402/ecrj.v1.24109OAI: oai:DiVA.org:uu-236887DiVA: diva2:765819
Available from: 2014-11-25 Created: 2014-11-25 Last updated: 2014-11-26Bibliographically approved

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Kämpe, MaryLisspers, KarinStällberg, BjörnJanson, Christer

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