uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Endostatin Level is Associated with Kidney Injury in the Elderly: Findings from Two Community-Based Cohorts
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Show others and affiliations
2014 (English)In: American Journal of Nephrology, ISSN 0250-8095, E-ISSN 1421-9670, Vol. 40, no 5, 417-424 p.Article in journal (Refereed) Published
Abstract [en]

Background: We aimed to investigate the associations between circulating endostatin and the different aspects of renal dysfunction, namely, estimated (cystatin C) glomerular filtration rate (GFR) and urine albumin-creatinine ratio (ACR).

Methods: Two independent longitudinal community-based cohorts of elderly. ULSAM, n = 786 men; age 78 years; median GFR 74 ml/min/1.73 m(2); median ACR 0.80 mg/mmol); and PIVUS, n = 815; age 75 years; 51% women; median GFR; 67 ml/min/1.73 m(2); median ACR 1.39 mg/mmol. Cross-sectional associations between the endostatin levels and GFR as well as ACR, and longitudinal association between endostatin at baseline and incident CKD (defined as GFR <60 ml/min/1.73 m(2)) were assessed.

Results: In cross-sectional regression analyses adjusting for age, gender, inflammation, and cardiovascular risk factors, serum endostatin was negatively associated with GFR (ULSAM: B-coefficient per SD increase -0.51, 95% CI (-0.57, -0.45), p < 0.001; PIVUS -0.47, 95% CI (-0.54, -0.41), p < 0.001) and positively associated with ACR (ULSAM: B-coefficient per SD increase 0.24, 95% CI (0.15, 0.32), p < 0.001; PIVUS 0.13, 95% CI (0.06-0.20), p < 0.001) in both cohorts. Moreover, in longitudinal multivariable analyses, higher endostatin levels were associated with increased risk for incident CKD defined as GFR <60 ml/min/1.73 m(2) at re-investigations in both ULSAM (odds ratio per SD increase of endostatin 1.39 (95% CI 1.01-1.90) and PIVUS 1.68 (95% CI 1.36-2.07)).

Conclusions: Higher circulating endostatin is associated with lower GFR and higher albuminuria and independently predicts incident CKD in elderly subjects. Further studies are warranted to investigate the underlying mechanisms linking endostatin to kidney pathology, and to evaluate the clinical relevance of our findings.

Place, publisher, year, edition, pages
2014. Vol. 40, no 5, 417-424 p.
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:uu:diva-237024DOI: 10.1159/000369076ISI: 000346347500004PubMedID: 25401956OAI: oai:DiVA.org:uu-237024DiVA: diva2:766085
Available from: 2014-11-26 Created: 2014-11-26 Last updated: 2017-12-05Bibliographically approved

Open Access in DiVA

fulltext(2192 kB)72 downloads
File information
File name FULLTEXT01.pdfFile size 2192 kBChecksum SHA-512
08f996848b1ee778444cc99191bd1d23f9b5370422345b1c59eaf6a8da39309f464e4c1c5bbbe7b8d7facac4b8a26359536620956f209bf781dc7a01222a9c50
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Carlsson, Axel CLarsson, AndersLind, LarsÄrnlöv, Johan

Search in DiVA

By author/editor
Carlsson, Axel CLarsson, AndersLind, LarsÄrnlöv, Johan
By organisation
Molecular epidemiologyScience for Life Laboratory, SciLifeLabClinical Nutrition and MetabolismDepartment of Medical Sciences
In the same journal
American Journal of Nephrology
Urology and Nephrology

Search outside of DiVA

GoogleGoogle Scholar
Total: 72 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 411 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf