uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Older Patients with Myeloma Derive Similar Benefit from Autologous Transplantation
Show others and affiliations
2014 (English)In: Biology of blood and marrow transplantation, ISSN 1083-8791, E-ISSN 1523-6536, Vol. 20, no 11, 1796-1803 p.Article in journal (Refereed) Published
Abstract [en]

Autologous hematopoietic cell transplantation (AHCT) for plasma cell myeloma is performed less often in people >70 years old than in people <= 70 years old. We analyzed 11,430 AHCT recipients for plasma cell myeloma prospectively reported to the Center for International Blood and Marrow Transplant Research between 2008 and 2011, representing the majority of US AHCT activity during this period. Survival (OS) was compared in 3 cohorts: ages 18 to 59 years (n = 5818), 60 to 69 years (n = 4666), and >70 years (n = 946). Median OS was not reached for any cohort. In multivariate analysis, increasing age was associated with mortality (P = .0006). Myeloma-specific mortality was similar among cohorts at 12%, indicating an age-related effect on nonmyeloma mortality. Analyses were performed in a representative subgroup comparing relapse rate, progression-free survival (PFS), and nonrelapse mortality (NRM). One-year NRM was 0% for age >70 years and 2% for other ages (P = not significant). The three-year relapse rate was 56% in age 18 to 59 years, 61% in age 60 to 69 years, and 63% age >70 (P = not significant). Three-year PFS was similar at 42% in age 18 to 59 years, 38% in age 60 to 69 years, and 33% in age >70 years (P = not significant). Postrelapse survival was significantly worse for the older cohort (P = .03). Older subjects selected for AHCT derived similar antimyeloma benefit without worse NRM, relapse rate, or PFS.

Place, publisher, year, edition, pages
2014. Vol. 20, no 11, 1796-1803 p.
Keyword [en]
Myeloma, Older patients, Autologous transplantation
National Category
Hematology Immunology in the medical area
URN: urn:nbn:se:uu:diva-236522DOI: 10.1016/j.bbmt.2014.07.013ISI: 000343364300021PubMedID: 25046833OAI: oai:DiVA.org:uu-236522DiVA: diva2:767386
Available from: 2014-12-01 Created: 2014-11-19 Last updated: 2014-12-01Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
In the same journal
Biology of blood and marrow transplantation
HematologyImmunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 200 hits
ReferencesLink to record
Permanent link

Direct link