Does locally delivered Zoledronate influence pen-implant bone formation?: Spatio-temporal monitoring of bone remodeling in vivo
2014 (English)In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 35, no 37, 9995-10006 p.Article in journal (Refereed) Published
Bisphosphonates are known for their strong inhibitory effect on bone resorption. Their influence on bone formation however is less clear. In this study we investigated the spatio-temporal effect of locally delivered Zoledronate on pen-implant bone formation and resorption in an ovariectomized rat femoral model. A cross-linked hyaluronic acid hydrogel was loaded with the drug and applied bilaterally in predrilled holes before inserting polymer screws. Static and dynamic bone parameters were analyzed based on in vivo microCT scans performed first weekly and then biweekly. The results showed that the locally released Zoledronate boosted bone formation rate up to 100% during the first 17 days after implantation and reduced the bone resorption rate up to 1000% later on. This shift in bone remodeling resulted in an increase in bone volume fraction (BV/TV) by 300% close to the screw and 100% further away. The double effect on bone formation and resorption indicates a great potential of Zoledronateloaded hydrogel for enhancement of pen-implant bone volume which is directly linked to improved implant fixation.
Place, publisher, year, edition, pages
2014. Vol. 35, no 37, 9995-10006 p.
Drug delivery, Hydrogel, Bisphosphonate, Implant, Dynamic histomorphometry, MicroCT
Biomaterials Science Engineering and Technology
IdentifiersURN: urn:nbn:se:uu:diva-237275DOI: 10.1016/j.biomaterials.2014.09.005ISI: 000343639700025PubMedID: 25241159OAI: oai:DiVA.org:uu-237275DiVA: diva2:768412