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Accuracy of the Finite Element Method in Deep Brain Stimulation Modelling
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
2014 (English)In: Proc. International Conference on Control Applications: CCA 2014, Piscataway, NJ: IEEE , 2014, p. 1479-1484Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Piscataway, NJ: IEEE , 2014. p. 1479-1484
National Category
Control Engineering Medical Equipment Engineering
Identifiers
URN: urn:nbn:se:uu:diva-238211DOI: 10.1109/CCA.2014.6981533ISI: 000366055800214ISBN: 978-1-4799-7409-2 (print)OAI: oai:DiVA.org:uu-238211DiVA, id: diva2:770421
Conference
CCA 2014, October 8–10, Antibes, France
Funder
EU, European Research Council, 247035
Available from: 2014-10-10 Created: 2014-12-10 Last updated: 2018-03-29Bibliographically approved
In thesis
1. Mathematical modeling for optimization of Deep Brain Stimulation
Open this publication in new window or tab >>Mathematical modeling for optimization of Deep Brain Stimulation
2016 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

Deep Brain Stimulation (DBS) consists of sending mild electric stimuli to the brain via a chronically implanted lead. The therapy is used to alleviate the symptoms of different neurological diseases, such as Parkinson's Disease. However, its underlying biological mechanism is currently unknown. DBS patients undergo a lengthy trial-and-error procedure in order to tune the stimuli so that the treatment achieves maximal therapeutic benefits while limiting side effects that are often present with large stimulation values.

The present licentiate thesis deals with mathematical modeling for DBS, extending it towards optimization. Mathematical modeling is motivated by the difficulty of obtaining in vivo measurements from the brain, especially in humans. It is expected to facilitate the optimization of the stimuli delivered to the brain and be instrumental in evaluating the performance of novel lead designs. Both topics are discussed in this thesis.

First, an analysis of numerical accuracy is presented in order to verify the DBS models utilized in this study. Then a performance comparison between a state-of-the-art lead and a novel field-steering lead using clinical settings is provided. Afterwards, optimization schemes using intersection of volumes and electric field control are described, together with some simplification tools, in order to speed up the computations involved in the modeling.

Place, publisher, year, edition, pages
Uppsala University, 2016
Series
Information technology licentiate theses: Licentiate theses from the Department of Information Technology, ISSN 1404-5117 ; 2016-002
National Category
Control Engineering Medical Equipment Engineering
Research subject
Electrical Engineering with specialization in Automatic Control
Identifiers
urn:nbn:se:uu:diva-284320 (URN)
Supervisors
Available from: 2016-01-22 Created: 2016-04-16 Last updated: 2017-08-31Bibliographically approved
2. Model-based optimization for individualized deep brain stimulation
Open this publication in new window or tab >>Model-based optimization for individualized deep brain stimulation
2018 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Deep Brain Stimulation (DBS) is an established therapy that is predominantly  utilized in treating the symptoms of neurodegenerative diseases such as Parkinson's Disease and Essential Tremor, crippling diseases like Chronic Pain and Epilepsy, and psychiatric diseases such as Schizophrenia and Depression. Due to its invasive nature, DBS is considered as a last resort therapy.DBS is performed by transmitting electric pulses through an electrode implanted in the brain of the patient.

The stimulation is driven by a battery-powered Implanted Pulse Generator. The brain is a very delicate and complex organ and, therefore, accurate positioning the electrode is vital. To achieve a satisfactory therapeutical result, the stimulation targets a certain predefined brain structure that depends on the disease.

The effect of DBS depends on the individual, the chosen stimulating contact(s), and the pulse parameters, i.e. amplitude, frequency, width, and shape. Tuning these parameters to the best effect is currently done by a lengthy trial-and-error process. Insufficient stimulation does not properly alleviate the symptoms of the disease, while overstimulation or stimulation off target is prone to side effects.

This work envisions assisting physicians in DBS therapy by utilizing model-based estimation and optimization, maximizing stimulation of the target and minimizing stimulation in potentially problematic areas of the brain. This work focuses on amplitude and contact selection. Because of inter-patient differences, individualized models based on clinical imaging have to be created. Alternatively, semi-individualized models can be designed using atlases that save time but potentially introduce inaccuracies. Other optimization  applications to DBS are proposed in the thesis, e.g. fault alleviation and electrode design.

Electrical properties of the brain can change over time and alter the stimulation spread. A system identification approach has been proposed to quantify these changes.

The main aim of DBS is to alleviate the symptoms of the disease and quantifying symptoms is important. The ultimate vision of this work is to design a closed-loop system that can deliver optimal stimulation to the brain while automatically adapting to changes in the brain and the severity of symptoms.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2018. p. 68
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1659
Keyword
Neuromodulation, Deep Brain Stimulation, Inverse Problems, Optimization, Finite Element Methods
National Category
Control Engineering
Research subject
Electrical Engineering with specialization in Automatic Control
Identifiers
urn:nbn:se:uu:diva-347353 (URN)978-91-513-0306-2 (ISBN)
Public defence
2018-05-25, ITC 2446 (Polacksbacken), Lägerhyddsvägen 2, Uppsala, 13:15 (English)
Opponent
Supervisors
Available from: 2018-05-03 Created: 2018-03-29 Last updated: 2018-05-04

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Cubo, RubénMedvedev, Alexander

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