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Association between trefoil factor 3 gene variants and idiopathic recurrent spontaneous abortion
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
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2014 (English)In: Reproductive Biomedicine Online, ISSN 1472-6483, Vol. 29, no 6, 737-44 p.Article in journal (Refereed) Published
Abstract [en]

Trefoil factor 3 (TFF3) gene is an inflammatory mediator expressed in human endometrium during the window of implantation. The aim of this study was to evaluate the possible genetic association of TFF3 variants in recurrent spontaneous abortion. Women with a history of recurrent spontaneous abortion (n = 164) and healthy pregnant women (n = 143) were genotyped for five TFF3 polymorphisms (rs225439 G/A, rs533093 C/T, rs225361 A/G, rs11701143 T/C and rs77436142 G/C). In addition, haplotypes formed within the gene were analysed. Within the recurrent spontaneous abortion group, women who at some point had given birth and childless women had 4.19 ± 1.75 and 5.34 ± 3.42 consecutive spontaneous abortions, respectively. Women who had experience recurrent spontaneous abortions had a lower allele frequency of the rs11701143 promoter region minor C allele compared with fertile women (0.02 versus 0.05, P = 0.015). Patients with rs225361 AG genotype had significantly more successful pregnancies before spontaneous abortion than those with homozygous AA and GG genotypes (P = 0.014). No significant differences in haplotype frequencies between patients and controls were detected. Possible genetic risk factors identified that might contribute to the pathogenesis of idiopathic recurrent spontaneous abortion were TFF3 gene variants.

Place, publisher, year, edition, pages
2014. Vol. 29, no 6, 737-44 p.
National Category
Obstetrics, Gynecology and Reproductive Medicine
URN: urn:nbn:se:uu:diva-238226DOI: 10.1016/j.rbmo.2014.08.007ISI: 000345759300012PubMedID: 25444508OAI: oai:DiVA.org:uu-238226DiVA: diva2:770470
Available from: 2014-12-10 Created: 2014-12-10 Last updated: 2015-01-07Bibliographically approved

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Karypidis, HelenaÅkerud, HelenaSundström-Poromaa, IngerStavreus-Evers, Anneli
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Obstetrics and GynaecologyDepartment of Women's and Children's Health
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Obstetrics, Gynecology and Reproductive Medicine

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