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Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
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2014 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 46, no 11, 1233-1238 p.Article in journal (Refereed) Published
Abstract [en]

Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 x 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 x 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 x 10(-13) and 3.63 x 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.

Place, publisher, year, edition, pages
2014. Vol. 46, no 11, 1233-1238 p.
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Medical Genetics
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URN: urn:nbn:se:uu:diva-238436DOI: 10.1038/ng.3105ISI: 000344131900015PubMedID: 25261932OAI: oai:DiVA.org:uu-238436DiVA: diva2:771046
Available from: 2014-12-12 Created: 2014-12-12 Last updated: 2017-12-05Bibliographically approved

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Glimelius, BengtVermeulen, Roel C. H.

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