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Functional magnetic resonance imaging in narcolepsy and the Kleine-Levin syndrome
Linkoping Univ, Dept Med & Hlth Sci IMH, Div Radiol Sci, Linkoping, Sweden; Linkoping Univ, Ctr Med Image Sci & Visualizat CMIV, Linkoping, Sweden.
Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Pediat, Gothenburg, Sweden.
Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Pediat, Gothenburg, Sweden; Halmstad Cty Hosp, Dept Pediat, Halmstad, Sweden.
Linkoping Univ, Ctr Med Image Sci & Visualizat CMIV, Linkoping, Sweden; Linkoping Univ, Div Disabil Res, Linkoping, Sweden; Linkoping Univ, Linnaeus Ctr HEAD, Dept Behav Sci & Learning, Linkoping, Sweden.
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2014 (English)In: Frontiers in Neurology, ISSN 1664-2295, E-ISSN 1664-2295, Vol. 5, 105Article in journal (Refereed) Published
Abstract [en]

This work aims at reviewing the present state of the art when it comes to understanding the pathophysiology of narcolepsy and the Kleine-Levin syndrome (KLS) from a neuroimaging point of view. This work also aims at discussing future perspectives of functional neuroimaging in these sleep disorders. We focus on functional magnetic resonance imaging (fMRI), which is a technique for in vivo measurements of brain activation in neuronal circuitries under healthy and pathological conditions. fMRI has significantly increased the knowledge on the affected neuronal circuitries in narcolepsy and the Kleine-Levin syndrome. It has been shown that narcolepsy is accompanied with disturbances of the emotional and the closely related reward systems. In the Kleine Levin syndrome, fMRI has identified hyperactivation of the thalamus as a potential biomarker that could be used in the diagnostic procedure. The fMRI findings in both narcolepsy and the Kleine-Levin syndrome are in line with previous structural and functional imaging studies. We conclude that fMRI in combination with multi-modal imaging can reveal important details about the pathophysiology in narcolepsy and the Kleine-Levin syndrome. In the future, fMRI possibly gives opportunities for diagnostic support and prediction of treatment response in individual patients.

Place, publisher, year, edition, pages
2014. Vol. 5, 105
Keyword [en]
functional magnetic resonance imaging, narcolepsy, hypersomnia, Kleine Levin syndrome, sleep, ascending arousal system, hypothalamus, thalamus
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-238766DOI: 10.3389/fneur.2014.00105ISI: 000209629300102PubMedID: 25009530OAI: oai:DiVA.org:uu-238766DiVA: diva2:772109
Available from: 2014-12-16 Created: 2014-12-16 Last updated: 2017-12-05Bibliographically approved

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Landtblom, Anne-Marie

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