uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
House dust-mite allergen exposure is associated with serum specific IgE but not with respiratory outcomes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine. (Eva Vingård)
Show others and affiliations
2015 (English)In: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668, Vol. 25, no 3, 235-244 p.Article in journal (Refereed) Published
Abstract [en]

Exposure to house dust has been associated with asthma in adults, and this is commonly interpreted as a direct immunologic response to dust-mite allergens in those who are IgE sensitized to house dust-mite. Mattress house dust-mite concentrations were measured in a population-based sample of 2890 adults aged between 27 and 56 years living in 22 centers in 10 countries. Generalized linear mixed models were employed to explore the association of respiratory symptoms with house dust-mite concentrations, adjusting for individual and household confounders. There was no overall association of respiratory outcomes with measured house dust-mite concentrations, even in those who reported they had symptoms on exposure to dust and those who had physician-diagnosed asthma. However, there was a positive association of high serum specific IgE levels to HDM (>3.5 kUA /l) with mattress house dust-mite concentrations and a negative association of sensitization to cat with increasing house dust-mite concentrations. In conclusion, there was no evidence that respiratory symptoms in adults were associated with exposure to house dust-mite allergen in the mattress, but an association of house mite with strong sensitization was observed.

Place, publisher, year, edition, pages
2015. Vol. 25, no 3, 235-244 p.
National Category
Environmental Health and Occupational Health
Research subject
Occupational and Environmental Medicine
URN: urn:nbn:se:uu:diva-238820DOI: 10.1111/ina.12137ISI: 000353502600002PubMedID: 24920489OAI: oai:DiVA.org:uu-238820DiVA: diva2:772307
Available from: 2014-12-16 Created: 2014-12-16 Last updated: 2015-06-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Norbäck, Dan
By organisation
Occupational and Environmental Medicine
In the same journal
Indoor Air
Environmental Health and Occupational Health

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 174 hits
ReferencesLink to record
Permanent link

Direct link