Long-term functional and radiological pulmonary changes after radiation therapy for breast cancer
2014 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 53, no 10, 1373-1379 p.Article in journal (Refereed) Published
Background. We assessed late functional and radiological pulmonary changes in breast cancer patients after a median of 11 years following radiotherapy (RT). Material and methods. Seventy women who received adjuvant loco-regional RT for breast cancer during November 1994-May 1998 accepted to participate in this follow-up study. Pulmonary function tests (PFTs) (n = 56) were compared to pre-RT examinations and diagnostic computer tomography (CT) of the lungs (n = 70) were performed and compared to four months post-RT examinations. Result. The median-matched vital capacity (VC), forced expiratory volume in one second (FEV1), and total lung capacity (TLC) were reduced 15%, 9%, and 7%, respectively, at the long-term follow-up (p < 0.001). We could not, however, detect a correlation between ipsilateral V-20 and VC-changes. Diffusion capacity (DLCO) appeared to improve compared with the pre-RT baseline level probably due to transient chemotherapy-induced toxicity. The median-matched percentage of the predicted DLCO 11 years after RT was, however, only 86%, indicating a chronic therapy-induced reduction also of this metric. According to the Arriagada classification, ipsilateral V-20 and long-term CT-changes showed a significant correlation (r(s) : 0. 57; p<0.001) in a small subset of the women. Conclusion. A chronic clinically significant reduction of PFTs compared to pre-RT values and CT-changes four months after RT were still detectable after a median follow-up of 11 years. There was a statistical correlation between V-20 and abnormalities on CT but no statistical correlation between V-20 and VC-changes.
Place, publisher, year, edition, pages
2014. Vol. 53, no 10, 1373-1379 p.
Cancer and Oncology
IdentifiersURN: urn:nbn:se:uu:diva-238578DOI: 10.3109/0284186X.2014.934967ISI: 000344005600013PubMedID: 25034350OAI: oai:DiVA.org:uu-238578DiVA: diva2:772380