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Season of infectious mononucleosis and risk of multiple sclerosis at different latitudes;: the EnvIMS Study
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2014 (English)In: Multiple Sclerosis, ISSN 1352-4585, E-ISSN 1477-0970, Vol. 20, no 6, 669-674 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Seasonal fluctuations in solar radiation and vitamin D levels could modulate the immune response against Epstein-Barr virus (EBV) infection and influence the subsequent risk of multiple sclerosis (MS).

METHODS: Altogether 1660 MS patients and 3050 controls from Norway and Italy participating in the multinational case-control study of Environmental Factors In Multiple Sclerosis (EnvIMS) reported season of past infectious mononucleosis (IM).

RESULTS: IM was generally reported more frequently in Norway (p=0.002), but was associated with MS to a similar degree in Norway (odds ratio (OR) 2.12, 95% confidence interval (CI) 1.64-2.73) and Italy (OR 1.72, 95% CI 1.17-2.52). For all participants, there was a higher reported frequency of IM during spring compared to fall (p<0.0005). Stratified by season of IM, the ORs for MS were 1.58 in spring (95% CI 1.08-2.31), 2.26 in summer (95% CI 1.46-3.51), 2.86 in fall (95% CI 1.69-4.85) and 2.30 in winter (95% CI 1.45-3.66).

CONCLUSIONS: IM is associated with MS independently of season, and the association is not stronger for IM during spring, when vitamin D levels reach nadir. The distribution of IM may point towards a correlation with solar radiation or other factors with a similar latitudinal and seasonal variation.

Place, publisher, year, edition, pages
2014. Vol. 20, no 6, 669-674 p.
National Category
URN: urn:nbn:se:uu:diva-238955DOI: 10.1177/1352458513505693PubMedID: 24072723OAI: oai:DiVA.org:uu-238955DiVA: diva2:772881
Available from: 2014-12-17 Created: 2014-12-17 Last updated: 2015-06-03Bibliographically approved

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Landtblom, Anne-Marie
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Multiple Sclerosis

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