Thalamic activation in the Kleine-Levin syndrome
2014 (English)In: Sleep, ISSN 0161-8105, E-ISSN 1550-9109, Vol. 37, no 2, 379-386 p.Article in journal (Refereed) Published
STUDY OBJECTIVES: The objective of this study was to investigate if combined measures of activation in the thalamus and working memory capacity could guide the diagnosis of Kleine-Levin Syndrome (KLS). A second objective was to obtain more insight into the neurobiological causes of KLS.
DESIGN: Matched group and consecutive recruitment.
SETTING: University hospital neurology department and imaging center.
PATIENTS OR PARTICIPANTS: Eighteen patients with KLS diagnosed according to the International Classification of Sleep Disorders and 26 healthy controls were included.
MEASUREMENTS AND RESULTS: Working memory capacity was assessed by the listening span task. A version of this task (reading span) was presented to the participants during functional magnetic resonance imaging (fMRI). Activation in the thalamus was measured in a region of interest analysis. A combination of the working memory capacity and the thalamic activation measures resulted in 80% prediction accuracy, 81% sensitivity, and 78% specificity regarding the ability to separate KLS patients from healthy controls. The controls had an inverse relation between working memory capacity and thalamic activation; higher performing participants had lower thalamic activation (r = -0.41). KLS patients showed the opposite relationship; higher performing participants had a tendency to higher thalamic activation (r = -0.35).
CONCLUSIONS: This study shows that functional neuroimaging of the thalamus combined with neuropsychological assessment of working memory function provides a means to guide diagnosis of Kleine-Levin Syndrome. Results in this study also indicate that imaging of brain function and evaluation of cognitive capacity can give insights into the neurobiological mechanisms of Kleine-Levin Syndrome.
Place, publisher, year, edition, pages
2014. Vol. 37, no 2, 379-386 p.
IdentifiersURN: urn:nbn:se:uu:diva-238961DOI: 10.5665/sleep.3420PubMedID: 24497666OAI: oai:DiVA.org:uu-238961DiVA: diva2:772889