uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Intravenous iron alone resolves anemia in patients with functional iron deficiency and lymphoid malignancies undergoing chemotherapy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
Show others and affiliations
2014 (English)In: Medical Oncology, ISSN 1357-0560, E-ISSN 1559-131X, Vol. 31, no 12, 302- p.Article in journal (Refereed) Published
Abstract [en]

This randomized trial evaluated ferric carboxymaltose without erythropoiesis-stimulating agents (ESA) for correction of anemia in cancer patients with functional iron deficiency. Patients on treatment for indolent lymphoid malignancies, who had anemia [hemoglobin (Hb) 8.5-10.5 g/dL] and functional iron deficiency [transferrin saturation (TSAT) <= 20 %, ferritin >30 ng/mL (women) or >40 ng/mL (men)], were randomized to ferric carboxymaltose (1,000 mg iron) or control. Primary end point was the mean change in Hb from baseline to weeks 4, 6 and 8 without transfusions or ESA. Difficulties with patient recruitment led to premature termination of the study. Seventeen patients (8 ferric carboxymaltose and 9 control) were included in the analysis. In the ferric carboxymaltose arm, mean Hb increase was significantly higher versus control at week 8 (p = 0.021). All ferric carboxymaltose- treated patients achieved an Hb increase >1 g/dL (control 6/9; p = 0.087), and mean TSAT was >20 % from week 2 onwards. No treatment-related adverse events were reported. In conclusion, ferric carboxymaltose without ESA effectively increased Hb and iron status in this small patient population.

Place, publisher, year, edition, pages
2014. Vol. 31, no 12, 302- p.
Keyword [en]
Ferric carboxymaltose, Intravenous iron, Anemia, Lymphoid malignancies, Functional iron deficiency
National Category
Cancer and Oncology
URN: urn:nbn:se:uu:diva-238394DOI: 10.1007/s12032-014-0302-3ISI: 000344531800019PubMedID: 25373320OAI: oai:DiVA.org:uu-238394DiVA: diva2:774315
Available from: 2014-12-22 Created: 2014-12-12 Last updated: 2014-12-22Bibliographically approved

Open Access in DiVA

fulltext(252 kB)42 downloads
File information
File name FULLTEXT01.pdfFile size 252 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Karlsson, TorbjörnBirgegård, Gunnar
By organisation
In the same journal
Medical Oncology
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 42 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 254 hits
ReferencesLink to record
Permanent link

Direct link