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Mutagenesis: smoking is associated with mosaic loss of chromosome Y
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
Södertörn University, School of Life Sciences, Biology, Huddinge, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
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2015 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 347, no 6217, 81-83 p.Article in journal (Refereed) Published
Abstract [en]

Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared to females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% CI = 2.8-6.7; ULSAM: OR = 2.4, 95% CI = 1.6-3.6; and PIVUS: OR = 3.5, 95% CI = 1.4-8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.

Place, publisher, year, edition, pages
2015. Vol. 347, no 6217, 81-83 p.
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Public Health, Global Health, Social Medicine and Epidemiology
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URN: urn:nbn:se:uu:diva-239522DOI: 10.1126/science.1262092ISI: 000347102300053PubMedID: 25477213OAI: oai:DiVA.org:uu-239522DiVA: diva2:774778
Available from: 2014-12-29 Created: 2014-12-29 Last updated: 2017-12-05Bibliographically approved

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Dumanski, Jan P.Rasi, ChiaraIngelsson, MartinGiedraitis, VilmantasLannfelt, LarsTiensuu Janson, EvaLind, LarsIngelsson, ErikForsberg, Lars A.

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Dumanski, Jan P.Rasi, ChiaraDavies, HannaIngelsson, MartinGiedraitis, VilmantasLannfelt, LarsTiensuu Janson, EvaLind, LarsIngelsson, ErikForsberg, Lars A.
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Medicinsk genetik och genomikScience for Life Laboratory, SciLifeLabGeriatricsEndocrine oncologyCardiovascular epidemiologyMolecular epidemiology
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