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Lessons and implications from association studies and post-GWAS analyses of cervical cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2015 (English)In: Trends in Genetics, ISSN 0168-9525, E-ISSN 1362-4555, Vol. 31, no 1, 41-54 p.Article, review/survey (Refereed) Published
Abstract [en]

Cervical cancer has a heritable genetic component. A large number of genetic associations with cervical cancer have been reported in hypothesis-driven candidate gene studies, but many of these results are either inconsistent or have failed to be independently replicated. Genome-wide association studies (GWAS) have identified additional susceptibility loci previously not implicated in cervical cancer development, highlighting the power of genome-wide unbiased association analyses. Post-GWAS analyses including pathway-based analysis and functional characterization of associated variants have provided new insights into the pathogenesis of cervical cancer. In this review we summarize findings from candidate gene association studies, GWAS, and post-GWAS analyses of cervical cancer. We also discuss gaps in our understanding, possible clinical implications of the findings, and lessons for studies of other complex diseases.

Place, publisher, year, edition, pages
2015. Vol. 31, no 1, 41-54 p.
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Basic Medicine
Identifiers
URN: urn:nbn:se:uu:diva-239525DOI: 10.1016/j.tig.2014.10.005ISI: 000347867200008PubMedID: 25467628OAI: oai:DiVA.org:uu-239525DiVA: diva2:774782
Available from: 2014-12-29 Created: 2014-12-29 Last updated: 2017-12-05Bibliographically approved

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Chen, DanGyllensten, Ulf

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