uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
MICA polymorphism: biology and importance in cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
2014 (English)In: Carcinogenesis, ISSN 0143-3334, E-ISSN 1460-2180, Vol. 35, no 12, 2633-2642 p.Article, review/survey (Refereed) Published
Abstract [en]

The major histocompatibility complex class I polypeptide-related sequence A gene (MICA) encodes a membrane-bound protein acting as a ligand to stimulate an activating receptor, NKG2D, expressed on the surface of essentially all human natural killer (NK), γδ T and CD8(+) αβ T cells. MICA protein is absent from most cells but can be induced by infections and oncogenic transformation and is frequently expressed in epithelial tumors. Upon binding to MICA, NKG2D activates cytolytic responses of NK and γδ T cells against infected and tumor cells expressing MICA. Therefore, membrane-bound MICA acts as a signal during the early immune response against infection or spontaneously arising tumors. On the other hand, human tumor cells spontaneously release a soluble form of MICA, causing the downregulation of NKG2D and in turn severe impairment of the antitumor immune response of NK and CD8(+) T cells. This is considered to promote tumor immune evasion and also to compromise host resistance to infections. MICA is the most polymorphic non-classical class I gene. A possible association of MICA polymorphism with genetic predisposition to different cancer types has been investigated in candidate gene-based studies. Two genome-wide association studies have identified loci in MICA that influence susceptibility to cervical neoplasia and hepatitis C virus-induced hepatocellular carcinoma, respectively. Given the current level of interest in the field of MICA gene, we discuss the genetics and biology of the MICA gene and the role of its polymorphism in cancer. Gaps in our understanding and future research needs are also discussed.

Place, publisher, year, edition, pages
2014. Vol. 35, no 12, 2633-2642 p.
National Category
Immunology in the medical area Cancer and Oncology
URN: urn:nbn:se:uu:diva-239527DOI: 10.1093/carcin/bgu215ISI: 000345836200001PubMedID: 25330802OAI: oai:DiVA.org:uu-239527DiVA: diva2:774783
Available from: 2014-12-29 Created: 2014-12-29 Last updated: 2015-01-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Gyllensten, Ulf
By organisation
Department of Immunology, Genetics and Pathology
In the same journal
Immunology in the medical areaCancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 186 hits
ReferencesLink to record
Permanent link

Direct link