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3D Texture Analysis in Renal Cell Carcinoma Tissue Image Grading
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Visual Information and Interaction. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computerized Image Analysis and Human-Computer Interaction.
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2014 (English)In: Computational & Mathematical Methods in Medicine, ISSN 1748-670X, E-ISSN 1748-6718, Vol. 2014, 536217:1-12 p.Article in journal (Refereed) Published
Abstract [en]

One of the most significant processes in cancer cell and tissue image analysis is the efficient extraction of features for grading purposes. This research applied two types of three-dimensional texture analysis methods to the extraction of feature values from renal cell carcinoma tissue images, and then evaluated the validity of the methods statistically through grade classification. First, we used a confocal laser scanning microscope to obtain image slices of four grades of renal cell carcinoma, which were then reconstructed into 3D volumes. Next, we extracted quantitative values using a 3D gray level cooccurrence matrix (GLCM) and a 3D wavelet based on two types of basis functions. To evaluate their validity, we predefined 6 different statistical classifiers and applied these to the extracted feature sets. In the grade classification results, 3D Haar wavelet texture features combined with principal component analysis showed the best discrimination results. Classification using 3D wavelet texture features was significantly better than 3D GLCM, suggesting that the former has potential for use in a computer-based grading system.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2014. Vol. 2014, 536217:1-12 p.
National Category
Medical Image Processing
URN: urn:nbn:se:uu:diva-239556DOI: 10.1155/2014/536217ISI: 000344657400001OAI: oai:DiVA.org:uu-239556DiVA: diva2:774839
Available from: 2014-10-09 Created: 2014-12-29 Last updated: 2015-03-04Bibliographically approved

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Bengtsson, Ewert
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Division of Visual Information and InteractionComputerized Image Analysis and Human-Computer Interaction
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