Replicability and Robustness of Genome-Wide-Association Studies for Behavioral Traits
2014 (English)In: Psychological Science, ISSN 0956-7976, E-ISSN 1467-9280, Vol. 25, no 11, 1975-1986 p.Article in journal (Refereed) Published
A recent genome-wide-association study of educational attainment identified three single-nucleotide polymorphisms (SNPs) whose associations, despite their small effect sizes (each R-2 approximate to 0.02%), reached genome-wide significance (p < 5 x 10(-8)) in a large discovery sample and were replicated in an independent sample (p < .05). The study also reported associations between educational attainment and indices of SNPs called polygenic scores. In three studies, we evaluated the robustness of these findings. Study 1 showed that the associations with all three SNPs were replicated in another large (N = 34,428) independent sample. We also found that the scores remained predictive (R-2 approximate to 2%) in regressions with stringent controls for stratification (Study 2) and in new within-family analyses (Study 3). Our results show that large and therefore well-powered genome-wide-association studies can identify replicable genetic associations with behavioral traits. The small effect sizes of individual SNPs are likely to be a major contributing factor explaining the striking contrast between our results and the disappointing replication record of most candidate-gene studies.
Place, publisher, year, edition, pages
2014. Vol. 25, no 11, 1975-1986 p.
IdentifiersURN: urn:nbn:se:uu:diva-239575DOI: 10.1177/0956797614545132ISI: 000344874900001PubMedID: 25287667OAI: oai:DiVA.org:uu-239575DiVA: diva2:775124