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Inhibition of cytochrome p450 brain aromatase reduces two male specific sexual behaviours in the male Endler guppy (Poecilia reticulata).
Södertörns Högskola.
Stockholms Universitet.
Södertörns Högskola.
2006 (English)In: General and Comparative Endocrinology, ISSN 0016-6480, E-ISSN 1095-6840, Vol. 147, no 3, 323-8 p.Article in journal (Refereed) Published
Abstract [en]

In mammalian and avian vertebrate groups, androgens act as controlling agents on male aggression and courtship behaviour by their conversion to oestrogens by cytochrome P450 aromatase in well-defined brain regions. Despite the fact that bony fishes have exceptionally high brain aromatase activity, little is known about it's possible regulatory effects on the reproductive behaviours of teleosts. In this study, Endler guppy males (Poecilia reticulata) were subjected to 26-29 days of 24-h exposure to two different concentrations (15 and 100 microg/L) of the aromatase inhibitor fadrozole in the water. Compared with the control males, two of three courtship activities in males exposed to the higher concentration were reduced when they were paired with receptive stimulus females. Reduction in brain aromatase activity was confirmed in both exposed groups with the use of the tritiated water assay.

Place, publisher, year, edition, pages
2006. Vol. 147, no 3, 323-8 p.
National Category
Natural Sciences
Research subject
Biology with specialization in Comparative Physiology
URN: urn:nbn:se:uu:diva-239925DOI: 10.1016/j.ygcen.2006.02.005PubMedID: 16563393OAI: oai:DiVA.org:uu-239925DiVA: diva2:775644
Available from: 2015-01-04 Created: 2015-01-04 Last updated: 2015-06-04

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Hallgren, Stefan L E
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