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Mortality in women with pregnancy-associated malignant melanoma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
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2014 (English)In: The Journal of American Academy of Dermatology, ISSN 0190-9622, E-ISSN 1097-6787, Vol. 71, no 6, 1093-1101 p.Article in journal (Refereed) Published
Abstract [en]

Background: Malignant melanoma (MM) is one of the most common malignancies in young women. It remains debated whether a MM diagnosed during pregnancy or lactation has a worse prognosis. Objective: We sought to examine mortality in women with pregnancy-associated MM (PAMM) (diagnosed during pregnancy and up to 2-years postpartum). Methods: This was a population-based cohort study based on information retrieved from the Swedish Cancer and Multi-Generation Registers. Hazard ratios with 95% confidence intervals adjusted for age, period, education, parity, and tumor location were estimated. Results: In total, 6857 women and girls aged 15 to 44 years with a diagnosis of cutaneous MM between 1963 and 2009 were identified. Of these, 1019 cases were classified as PAMM. The cause-specific mortality did not differ between PAMM and MM not diagnosed near childbirth (adjusted hazard ratio 1.09, 95% confidence interval 0.83-1.42). Limitations: Information on stage at diagnosis was available only for a subset of patients Conclusion: Overall, the cause-specific mortality in women and girls with PAMM did not differ from that in women and girls with non-PAMM. The current findings do not provide evidence of an adverse prognostic influence of pregnancy or a recent birth.

Place, publisher, year, edition, pages
2014. Vol. 71, no 6, 1093-1101 p.
Keyword [en]
malignant melanoma, mortality, pregnancy, stage, survival, Sweden
National Category
Cancer and Oncology
URN: urn:nbn:se:uu:diva-240079DOI: 10.1016/j.jaad.2014.09.018ISI: 000345232400018PubMedID: 25440438OAI: oai:DiVA.org:uu-240079DiVA: diva2:775958
Available from: 2015-01-05 Created: 2015-01-05 Last updated: 2015-01-05Bibliographically approved

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