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The glioblastoma vasculature as a target for cancer therapy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Cancer and Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2014 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 42, 1647-1652 p.Article in journal (Refereed) Published
Abstract [en]

Glioblastoma is characterized by microvascular proliferation and a highly abnormal dysfunctional vasculature. The glioblastoma vessels differ significantly from normal brain vessels morphologically, functionally and molecularly. The present review provides a brief overview of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment.

Place, publisher, year, edition, pages
2014. Vol. 42, 1647-1652 p.
Keyword [en]
anti-angiogenic therapy, endothelium, gene expression, glioblastoma, tumour, vascular abnormalization
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:uu:diva-240066DOI: 10.1042/BST20140278ISI: 000345427100028PubMedID: 25399584OAI: oai:DiVA.org:uu-240066DiVA: diva2:775967
Available from: 2015-01-05 Created: 2015-01-05 Last updated: 2015-01-05Bibliographically approved

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