The glioblastoma vasculature as a target for cancer therapy
2014 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 42, 1647-1652 p.Article in journal (Refereed) Published
Glioblastoma is characterized by microvascular proliferation and a highly abnormal dysfunctional vasculature. The glioblastoma vessels differ significantly from normal brain vessels morphologically, functionally and molecularly. The present review provides a brief overview of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment.
Place, publisher, year, edition, pages
2014. Vol. 42, 1647-1652 p.
anti-angiogenic therapy, endothelium, gene expression, glioblastoma, tumour, vascular abnormalization
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:uu:diva-240066DOI: 10.1042/BST20140278ISI: 000345427100028PubMedID: 25399584OAI: oai:DiVA.org:uu-240066DiVA: diva2:775967