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Therapeutic vaccination targeting the tumour vasculature
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2014 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 42, 1653-1657 p.Article in journal (Refereed) Published
Abstract [en]

Therapeutic vaccination targeting self-molecules could provide a cost-efficient alternative to monoclonal antibody-based therapies for cancer and various inflammatory diseases. However, development of cancer vaccines targeting self-molecules has proven difficult. One complicating factor is that tumour cells have developed strategies to escape recognition by the immune system. Antigens specifically expressed by the tumour vasculature can therefore provide alternative targets. The present mini-review highlights potential target molecules associated with tumour angiogenesis and the approaches made to direct an immune response against them. Furthermore, the requirements on a vaccine targeting self-molecules, in contrast with those directed against virus or bacteria, are discussed.

Place, publisher, year, edition, pages
2014. Vol. 42, 1653-1657 p.
Keyword [en]
cancer vaccine, immunization, therapeutic vaccination, tumour vasculature
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-240067DOI: 10.1042/BST20140196ISI: 000345427100029PubMedID: 25399585OAI: oai:DiVA.org:uu-240067DiVA: diva2:775968
Funder
Swedish Research Council, 2010-6903-75363-44Swedish Cancer Society, 11 0653
Available from: 2015-01-05 Created: 2015-01-05 Last updated: 2017-12-05Bibliographically approved

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Olsson, Anna-Karin

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