Therapeutic vaccination targeting the tumour vasculature
2014 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 42, 1653-1657 p.Article in journal (Refereed) Published
Therapeutic vaccination targeting self-molecules could provide a cost-efficient alternative to monoclonal antibody-based therapies for cancer and various inflammatory diseases. However, development of cancer vaccines targeting self-molecules has proven difficult. One complicating factor is that tumour cells have developed strategies to escape recognition by the immune system. Antigens specifically expressed by the tumour vasculature can therefore provide alternative targets. The present mini-review highlights potential target molecules associated with tumour angiogenesis and the approaches made to direct an immune response against them. Furthermore, the requirements on a vaccine targeting self-molecules, in contrast with those directed against virus or bacteria, are discussed.
Place, publisher, year, edition, pages
2014. Vol. 42, 1653-1657 p.
cancer vaccine, immunization, therapeutic vaccination, tumour vasculature
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:uu:diva-240067DOI: 10.1042/BST20140196ISI: 000345427100029PubMedID: 25399585OAI: oai:DiVA.org:uu-240067DiVA: diva2:775968
FunderSwedish Research Council, 2010-6903-75363-44Swedish Cancer Society, 11 0653